QuickView for AFP (gene)

Gene Symbol:

AFP Homo sapiens

Full name:

alpha fetoprotein

Synonyms:

AFPD, FETA, HPAFP, alpha-fetoprotein, alpha-1-fetoprotein, alpha-fetoglobulin

Genomic Location:

Chr 4: 74520797-74540356

Description:

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the ...

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This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF1_01 ,  YGTCCTTGR_UNKNOWN ,  HP1SITEFACTOR_Q6 ,  HNF1_C ,  STAT1_03 ,  CDP_01 ,  TATAAA_TATA_01 ,  PAX4_02 ,  TAATTA_CHX10_01 ,  ERR1_Q2 ,  HNF1_Q6

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Cytogenetic Map:

4q13.3

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