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QuickView for AGO1;jsessionid=7E2F3F547E520AA5324A79A9E7005B90 (gene)


Gene Symbol:
AGO1 Homo sapiens Homo sapiens
Full name:
argonaute 1, RISC catalytic component
Synonyms:
EIF2C, EIF2C1, GERP95, Q99, hAgo1, protein argonaute-1, Golgi Endoplasmic Reticulum protein 95 kDa, argonaute RISC catalytic component 1, argonaute1, eIF-2C 1, eIF2C 1, eukaryotic translation initiation factor 2C, 1, putative RNA-binding protein Q99
Genomic Location:
Chr 1: 36121397-36162486
Description:
This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional g...
Orthologs:
Mus musculus Rattus norvegicus Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
E12_Q6 ACAACCT_MIR453 MYOD_Q6_01 TTTGCAC_MIR19A_MIR19B GAGCCTG_MIR484 MYOD_01 AAGCCAT_MIR135A_MIR135B ACACTCC_MIR122A GCATTTG_MIR105 MZF1_01
miRNA binding sites
(Source: TargetScan):
Predicted Gene Targets for let-7 Predicted Gene Targets for miR-1 Predicted Gene Targets for miR-103 Predicted Gene Targets for miR-122a Predicted Gene Targets for miR-130 Predicted Gene Targets for miR-133 Predicted Gene Targets for miR-135 Predicted Gene Targets for miR-138 Predicted Gene Targets for miR-148 Predicted Gene Targets for miR-15
Cytogenetic Map:
chr 1
1p34.3





GO Molecular Function

sequence-specific DNA binding | RNA polymerase II complex binding | nuclease activity | transcription regulatory region DNA binding | core promoter binding | RNA polymerase binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | hydrolase activity | ribonuclease activity | catalytic activity | single-stranded RNA binding | RNA polymerase II regulatory region DNA binding | miRNA binding | DNA binding | sequence-specific double-stranded DNA binding | RNA polymerase core enzyme binding | hydrolase activity, acting on ester bonds | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | endoribonuclease activity | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | RNA polymerase II regulatory region sequence-specific DNA binding | endonuclease activity | basal RNA polymerase II transcription machinery binding | heterocyclic compound binding | RNA binding | double-stranded RNA binding

GO Biological Process

RNA metabolic process | gene silencing by RNA | positive regulation of macromolecule biosynthetic process | RNA processing | mRNA cleavage | nuclease activity | regulation of immune system process | small RNA loading onto RISC | negative regulation of cellular process | production of small RNA involved in gene silencing by RNA | negative regulation of translation, ncRNA-mediated | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | organic substance catabolic process | dsRNA fragmentation | regulation of megakaryocyte differentiation | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cell differentiation | regulation of angiogenesis | regulation of cellular process | gene silencing | regulation of metabolic process | catabolic process | production of miRNAs involved in gene silencing by miRNA | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of gene silencing by miRNA | cellular component organization | mRNA catabolic process | regulation of vasculature development | response to stimulus | miRNA loading onto RISC involved in gene silencing by miRNA | positive regulation of NIK/NF-kappaB signaling | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | negative regulation of angiogenesis | ncRNA processing | regulation of gene silencing | cellular nitrogen compound metabolic process | nucleic acid phosphodiester bond hydrolysis | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | mRNA metabolic process | ribonuclease activity | nuclear-transcribed mRNA catabolic process | cellular biosynthetic process | nucleobase-containing compound catabolic process | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of nucleic acid-templated transcription | response to nitrogen compound | RNA interference | nitrogen compound metabolic process | regulation of signal transduction | Wnt signaling pathway | response to dsRNA | miRNA mediated inhibition of translation | regulation of gene expression | gene silencing by miRNA | RNA catabolic process | positive regulation of cellular metabolic process | mRNA cleavage involved in gene silencing by miRNA | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | non-canonical Wnt signaling pathway | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | cellular protein-containing complex assembly | posttranscriptional gene silencing | cell communication | regulation of cellular metabolic process | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | aromatic compound catabolic process | cellular response to dsRNA | regulation of RNA metabolic process | endoribonuclease activity | Wnt signaling pathway, calcium modulating pathway | protein-containing complex assembly | posttranscriptional gene silencing by RNA | response to organic substance | regulation of hemopoiesis | regulation of intracellular signal transduction | cellular macromolecule catabolic process | cell surface receptor signaling pathway | metabolic process | RNA phosphodiester bond hydrolysis, endonucleolytic | regulation of RNA biosynthetic process | regulation of gene silencing by RNA | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | RNA secondary structure unwinding | negative regulation of gene expression | RNA phosphodiester bond hydrolysis | negative regulation of cellular protein metabolic process | gene expression | endonuclease activity | ribonucleoprotein complex assembly | negative regulation of translation | transcription, DNA-templated | negative regulation of protein metabolic process | regulation of cell communication | signaling | pre-miRNA processing | regulation of transcription, DNA-templated | response to organic cyclic compound | mRNA cleavage involved in gene silencing by siRNA | cellular macromolecule biosynthetic process | regulation of developmental process | positive regulation of transcription, DNA-templated | ncRNA metabolic process | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | ribonucleoprotein complex biogenesis | cellular metabolic process | cellular response to organic substance | regulation of translation | miRNA metabolic process | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | catalytic complex | polysome | cell | nuclear lumen | ribonucleoprotein granule | RISC complex | cytoplasm | intracellular organelle | P-body | micro-ribonucleoprotein complex | protein-containing complex | RNAi effector complex | nucleoplasm | RISC-loading complex | ribonucleoprotein complex | membrane-bounded organelle | nucleus | organelle | cytoplasmic ribonucleoprotein granule | membrane-enclosed lumen | cytosol | intracellular