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QuickView for AKR1B1 (gene)


Gene Symbol:
AKR1B1 Homo sapiens Homo sapiens
Full name:
aldo-keto reductase family 1 member B
Synonyms:
ADR, ALDR1, ALR2, AR, aldose reductase, Lii5-2 CTCL tumor antigen, aldehyde reductase 1, aldo-keto reductase family 1 member B1, low Km aldose reductase
Genomic Location:
Chr 7: 133777647-133794428
Description:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol....
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Bos taurus Danio rerio Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 7
7q33





GO Molecular Function

oxidoreductase activity, acting on CH-OH group of donors | glyceraldehyde oxidoreductase activity | alcohol dehydrogenase (NADP+) activity | aldo-keto reductase (NADP) activity | catalytic activity | electron transfer activity | alditol:NADP+ 1-oxidoreductase activity | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | oxidoreductase activity

GO Biological Process

positive regulation of smooth muscle cell proliferation | hyperosmotic response | oxidoreductase activity, acting on CH-OH group of donors | sorbitol biosynthetic process | intracellular signal transduction | catechol-containing compound metabolic process | regulation of programmed cell death | response to hormone | negative regulation of cellular process | response to water | generation of precursor metabolites and energy | renal water homeostasis | naphthalene metabolic process | polyol metabolic process | tissue homeostasis | phenol-containing compound metabolic process | cellular process | glyceraldehyde oxidoreductase activity | female pregnancy | multicellular organismal reproductive process | negative regulation of apoptotic process | response to inorganic substance | anatomical structure homeostasis | cellular hyperosmotic salinity response | regulation of cellular process | regulation of apoptotic process | organic cyclic compound metabolic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | steroid biosynthetic process | regulation of urine volume | urogenital system development | alcohol dehydrogenase (NADP+) activity | response to stimulus | collecting duct development | response to salt stress | response to stress | positive regulation of JAK-STAT cascade | alcohol metabolic process | regulation of cell proliferation | multicellular organismal homeostasis | aldo-keto reductase (NADP) activity | electron transport chain | response to peptide | reproduction | cofactor metabolic process | fructose metabolic process | cellular biosynthetic process | kidney development | stress-activated protein kinase signaling cascade | water homeostasis | organic hydroxy compound metabolic process | response to nitrogen compound | system development | fructose biosynthetic process | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | multicellular organism development | antibiotic metabolic process | hormone biosynthetic process | lipid metabolic process | regulation of hormone levels | electron transfer activity | response to ketone | cellular response to stress | cellular response to peptide | hexose biosynthetic process | monosaccharide metabolic process | small molecule metabolic process | cellular carbohydrate metabolic process | positive regulation of STAT cascade | positive regulation of intracellular signal transduction | daunorubicin metabolic process | carbohydrate biosynthetic process | cellular ketone metabolic process | biosynthetic process | response to osmotic stress | alditol:NADP+ 1-oxidoreductase activity | lipid biosynthetic process | norepinephrine metabolic process | carbohydrate metabolic process | response to methylglyoxal | cell communication | positive regulation of signal transduction | homeostatic process | positive regulation of cell proliferation | renal system development | cellular hyperosmotic response | drug metabolic process | multicellular organism reproduction | maternal process involved in female pregnancy | response to organic substance | inner medullary collecting duct development | regulation of JAK-STAT cascade | catecholamine metabolic process | cellular response to osmotic stress | regulation of intracellular signal transduction | anatomical structure development | metabolic process | hexose metabolic process | regulation of body fluid levels | oxidation-reduction process | negative regulation of programmed cell death | doxorubicin metabolic process | chemical homeostasis | sorbitol metabolic process | glycoside metabolic process | organic substance metabolic process | animal organ development | C21-steroid hormone metabolic process | cellular response to salt stress | renal system process | hyperosmotic salinity response | response to water deprivation | steroid metabolic process | regulation of cell communication | signaling | hormone metabolic process | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | developmental process | response to thyroid hormone | C21-steroid hormone biosynthetic process | tube development | carbohydrate derivative metabolic process | quinone metabolic process | multicellular organismal water homeostasis | response to organonitrogen compound | cellular response to methylglyoxal | cellular metabolic process | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | oxidoreductase activity | negative regulation of cell death | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | actin-based cell projection | cell | nuclear lumen | mast cell granule | compact myelin | cytoplasm | intracellular organelle | cell-cell junction | glial cell projection | cell projection | nucleoplasm | plasma membrane bounded cell projection cytoplasm | vacuole | vesicle | perinuclear region of cytoplasm | extracellular exosome | cytoplasmic region | lytic vacuole | extracellular region | microvillus | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | lysosome | extracellular space | membrane-enclosed lumen | Schwann cell microvillus | paranodal junction | Schmidt-Lanterman incisure | cytosol | intracellular | cell junction | myelin sheath