QuickView for AKT1 (gene)
- Gene Symbol:
- AKT1
Homo sapiens - Full name:
- AKT serine/threonine kinase 1
- Synonyms:
- AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA, RAC-alpha serine/threonine-protein kinase, AKT1m, PKB alpha, RAC-PK-alpha, protein kinase B alpha, proto-oncogene c-Akt, rac protein kinase alpha, serine-threonine protein kinase, v-akt murine thymoma viral oncogene homolog 1, v-akt murine thymoma viral oncogene-like protein 1
- Genomic Location:
- Chr 14: 104306731-104333125
- Description:
-
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that t...
- Orthologs:
- Mus musculus , Rattus norvegicus , C. elegans , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
14q32.33
GO Molecular Function
kinase binding | protein phosphatase 2A binding | 14-3-3 protein binding | protein kinase binding | enzyme binding | ribonucleotide binding | lipid binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | phospholipid binding | phosphatidylinositol-3,4-bisphosphate binding | molecular function regulator | catalytic activity | ATP binding | protein kinase C binding | anion binding | adenyl nucleotide binding | phosphatidylinositol bisphosphate binding | purine nucleotide binding | identical protein binding | ion binding | phosphatidylinositol-3,4,5-trisphosphate binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | GTPase activating protein binding | protein phosphatase binding | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | nitric-oxide synthase regulator activity | protein kinase activity | phosphatidylinositol binding | transferase activity | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | protein serine/threonine/tyrosine kinase activity | drug binding | kinase activity | phosphatase binding | heterocyclic compound binding | small molecule binding | phosphatidylinositol phosphate binding
GO Biological Process
positive regulation of cyclin-dependent protein serine/threonine kinase activity | leukocyte homeostasis | positive regulation of smooth muscle cell proliferation | response to extracellular stimulus | negative regulation of JNK cascade | response to insulin-like growth factor stimulus | negative regulation of phosphorylation | positive regulation of glycogen biosynthetic process | regulation of blood vessel diameter | response to radiation | regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of cell cycle process | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | response to nutrient levels | negative regulation of MAPK cascade | positive regulation of blood circulation | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle | response to cytokine | regulation of cellular response to oxidative stress | regulation of response to oxidative stress | regulation of neurogenesis | response to lipopolysaccharide | developmental process involved in reproduction | regulation of cellular localization | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | protein localization to mitochondrion | regulation of localization | regulation of cell cycle G1/S phase transition | positive regulation of DNA-binding transcription factor activity | regulation of carbohydrate metabolic process | regulation of programmed cell death | regulation of sodium ion transport | negative regulation of cellular response to oxidative stress | peptidyl-amino acid modification | Schwann cell differentiation | negative regulation of cysteine-type endopeptidase activity | nitric oxide biosynthetic process | establishment of localization | regulation of autophagy | regulation of immune system process | response to hormone | regulation of nitric oxide biosynthetic process | negative regulation of neuron death | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | response to metal ion | glucose metabolic process | cellular response to tumor necrosis factor | positive regulation of lymphocyte activation | regulation of protein localization to membrane | cell differentiation | positive regulation of epithelial cell proliferation | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | excitatory postsynaptic potential | maternal placenta development | defense response | nervous system development | negative regulation of mitochondrion organization | response to growth hormone | positive regulation of protein catabolic process | lymphocyte costimulation | reactive oxygen species metabolic process | generation of precursor metabolites and energy | negative regulation of protein phosphorylation | regulation of G1/S transition of mitotic cell cycle | neurogenesis | glucose homeostasis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | regulation of fibroblast migration | generation of neurons | membrane organization | intracellular transport | regulation of lipid transport | negative regulation of proteolysis | glycogen cell differentiation involved in embryonic placenta development | regulation of neuron death | negative regulation of stress-activated protein kinase signaling cascade | positive regulation of cellular biosynthetic process | cellular process | peripheral nervous system development | organic substance catabolic process | cellular response to granulocyte macrophage colony-stimulating factor stimulus | regulation of glucose import | regulation of cell motility | localization | axon ensheathment | protein transport | regulation of mitochondrial membrane potential | negative regulation of macroautophagy | negative regulation of signaling | chemical synaptic transmission | positive regulation of peptidyl-serine phosphorylation | positive regulation of reactive oxygen species metabolic process | reproductive system development | positive regulation of membrane potential | TOR signaling | female pregnancy | establishment of protein localization to mitochondrion | positive regulation of nitric-oxide synthase activity | multicellular organismal reproductive process | positive regulation of protein kinase activity | macromolecule localization | negative regulation of apoptotic process | endomembrane system organization | response to hypoxia | positive regulation of oxidoreductase activity | regulation of proteolysis | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | glycogen biosynthetic process | negative regulation of release of cytochrome c from mitochondria | positive regulation of nitrogen compound metabolic process | myelin maintenance | regulation of neuron projection development | response to inorganic substance | establishment of localization in cell | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of binding | regulation of fat cell differentiation | regulation of cell differentiation | gamete generation | muscle structure development | muscle cell differentiation | positive regulation of vasoconstriction | response to prostaglandin | negative regulation of apoptotic signaling pathway | regulation of mRNA stability | cellular polysaccharide biosynthetic process | regulation of protein kinase B signaling | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | cellular response to prostaglandin stimulus | gliogenesis | catabolic process | cellular response to molecule of bacterial origin | positive regulation of cyclin-dependent protein kinase activity | protein import into nucleus | response to nerve growth factor | regulation of endodeoxyribonuclease activity | epidermal growth factor receptor signaling pathway | positive regulation of cellular protein metabolic process | negative regulation of oxidative stress-induced cell death | epithelium development | cellular response to organonitrogen compound | insulin-like growth factor receptor signaling pathway | maintenance of protein location in mitochondrion | endocrine pancreas development | cellular component organization | cellular response to metal ion | positive regulation of epithelial cell migration | response to UV | positive regulation of cellular protein catabolic process | response to stimulus | peptidyl-threonine phosphorylation | positive regulation of I-kappaB phosphorylation | vasculature development | cellular response to vascular endothelial growth factor stimulus | peptide biosynthetic process | regulation of cellular protein localization | cellular response to mechanical stimulus | regulation of mitotic cell cycle phase transition | positive regulation of nitric oxide metabolic process | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | regulation of blood vessel size | cellular response to hypoxia | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | response to stress | intracellular protein transport | cellular polysaccharide metabolic process | germ cell development | negative regulation of protein kinase activity | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | regulation of cell proliferation | positive regulation of lipid biosynthetic process | peripheral nervous system myelin maintenance | regulation of protein ubiquitination | regulation of blood circulation | polysaccharide metabolic process | response to peptide | positive regulation of cell-cell adhesion | protein localization to nucleus | positive regulation of glucose import | regulation of cell cycle phase transition | ensheathment of neurons | execution phase of apoptosis | protein serine/threonine kinase activity | programmed cell death | phosphatidylinositol-mediated signaling | positive regulation of proteolysis involved in cellular protein catabolic process | positive regulation of cell activation | reproduction | cellular response to inorganic substance | cellular localization | response to alcohol | cardiovascular system development | response to temperature stimulus | cellular response to cadmium ion | positive regulation of proteolysis | response to molecule of bacterial origin | positive regulation of fibroblast migration | cellular nitrogen compound metabolic process | maintenance of protein localization in organelle | positive regulation of nuclease activity | positive regulation of T cell activation | regulation of macroautophagy | negative regulation of transport | apoptotic mitochondrial changes | positive regulation of blood vessel endothelial cell migration | cellular response to organic cyclic compound | ERBB signaling pathway | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | regulation of cellular component size | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | cofactor metabolic process | protein modification process | reactive oxygen species biosynthetic process | regulation of cell adhesion | cellular biosynthetic process | embryo development | mitochondrion organization | macromolecule modification | cell-cell signaling | negative regulation of transmembrane transport | activation of protein kinase activity | positive regulation of ERBB signaling pathway | molecular function regulator | cell surface receptor signaling pathway involved in cell-cell signaling | embryonic placenta development | positive regulation of deoxyribonuclease activity | blood vessel development | interleukin-18-mediated signaling pathway | regulation of nucleic acid-templated transcription | regulation of membrane potential | regulation of cellular response to stress | regulation of neurotransmitter levels | positive regulation of monooxygenase activity | response to nitrogen compound | apoptotic process | protein kinase B signaling | cellular response to hormone stimulus | positive regulation of reactive oxygen species biosynthetic process | response to light stimulus | response to external biotic stimulus | system development | regulation of cyclin-dependent protein serine/threonine kinase activity | response to oxygen levels | glycogen metabolic process | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | regulation of fatty acid beta-oxidation | negative regulation of phosphate metabolic process | myelination | multicellular organism development | negative regulation of catalytic activity | response to UV-A | cellular response to peptide hormone stimulus | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | response to granulocyte macrophage colony-stimulating factor | negative regulation of lipid catabolic process | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | mammary gland development | response to fatty acid | protein import into nucleus, translocation | cellular response to DNA damage stimulus | cellular response to insulin stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of protein localization to cell surface | cellular response to oxidative stress | cellular response to nerve growth factor stimulus | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | hyaluronan metabolic process | polysaccharide biosynthetic process | negative regulation of peptidase activity | negative regulation of protein kinase activity by protein phosphorylation | plasma membrane organization | regulation of nitric-oxide synthase activity | anoikis | regulation of T cell activation | cellular response to prostaglandin E stimulus | positive regulation of cell cycle | positive regulation of protein localization to plasma membrane | regulation of neuron differentiation | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | positive regulation of protein localization to cell surface | response to prostaglandin E | regulation of postsynaptic membrane potential | pancreas development | organic substance transport | response to ketone | cellular response to stress | response to lipid | nervous system process | cellular response to peptide | protein catabolic process | synaptic signaling | insulin receptor signaling pathway | regulation of signal transduction by p53 class mediator | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | cellular response to interleukin-18 | negative regulation of fatty acid oxidation | regulation of protein localization to nucleus | cellular response to oxygen levels | regulation of myelination | protein autophosphorylation | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | placenta blood vessel development | regulation of cell migration | regulation of Notch signaling pathway | enzyme linked receptor protein signaling pathway | monosaccharide metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | small molecule metabolic process | cellular carbohydrate metabolic process | peptide transport | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of RNA stability | negative regulation of protein serine/threonine kinase activity | cellular amide metabolic process | regulation of cellular component movement | regulation of transcription by RNA polymerase II | response to oxidative stress | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | protein localization to organelle | negative regulation of binding | positive regulation of hydrolase activity | import into nucleus | regulation of fatty acid metabolic process | translation | positive regulation of cell differentiation | regulation of endothelial cell migration | activation of protein kinase B activity | negative regulation of extrinsic apoptotic signaling pathway | homeostasis of number of cells | neurotransmitter metabolic process | T cell apoptotic process | positive regulation of cell migration | negative regulation of ion transmembrane transport | carbohydrate biosynthetic process | cellular response to cytokine stimulus | positive regulation of glucose transmembrane transport | cell proliferation | positive regulation of protein localization to nucleus | biosynthetic process | negative regulation of protein kinase B signaling | response to cadmium ion | cell differentiation involved in embryonic placenta development | labyrinthine layer development | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | glial cell differentiation | phosphorylation | negative regulation of ion transport | negative regulation of stress-activated MAPK cascade | carbohydrate metabolic process | inositol lipid-mediated signaling | regulation of apoptotic signaling pathway | labyrinthine layer blood vessel development | endocrine system development | protein phosphorylation | phosphate-containing compound metabolic process | negative regulation of autophagy | protein import | regulation of mitochondrion organization | maintenance of protein location | response to bacterium | chordate embryonic development | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of protein localization to membrane | regulation of lipid catabolic process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | lymphocyte homeostasis | inflammatory response | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | peptide metabolic process | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | negative regulation of protein ubiquitination | lipopolysaccharide-mediated signaling pathway | regulation of tube size | positive regulation of transport | regulation of lipid biosynthetic process | carbohydrate transport | striated muscle cell differentiation | cellular response to fatty acid | regulation of mitotic cell cycle | activation-induced cell death of T cells | drug metabolic process | carboxylic acid metabolic process | positive regulation of molecular function | regulation of proteasomal ubiquitin-dependent protein catabolic process | cellular response to epidermal growth factor stimulus | multicellular organism reproduction | maternal process involved in female pregnancy | negative regulation of lipid transport | reactive nitrogen species metabolic process | positive regulation of organ growth | protein metabolic process | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | protein ubiquitination | regulation of kinase activity | response to mechanical stimulus | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | phosphatidylinositol 3-kinase signaling | establishment of protein localization to organelle | response to insulin | anatomical structure development | Schwann cell development | cell surface receptor signaling pathway | regulation of vasoconstriction | regulation of glucose metabolic process | negative regulation of lipid metabolic process | cell projection organization | metabolic process | negative regulation of response to oxidative stress | negative regulation of fatty acid transport | positive regulation of glucose metabolic process | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of protein localization to plasma membrane | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | hexose metabolic process | oxidation-reduction process | negative regulation of programmed cell death | embryonic organ development | regulation of proteasomal protein catabolic process | negative regulation of cell size | regulation of tube diameter | cellular protein localization | amide transport | nitric-oxide synthase regulator activity | chemical homeostasis | positive regulation of cell death | glucan biosynthetic process | protein kinase activity | cellular response to reactive oxygen species | organic substance metabolic process | regulation of epidermal growth factor receptor signaling pathway | negative regulation of intrinsic apoptotic signaling pathway | nuclear transport | cell death | negative regulation of gene expression | regulation of glucose transmembrane transport | animal organ development | positive regulation of ion transport | response to reactive oxygen species | regulation of mRNA catabolic process | regulation of endothelial cell proliferation | positive regulation of sodium ion transport | negative regulation of cellular protein metabolic process | gene expression | amide biosynthetic process | regulation of cell activation | positive regulation of programmed cell death | positive regulation of kinase activity | response to heat | regulation of fatty acid oxidation | protein modification by small protein conjugation or removal | maintenance of protein location in cell | regulation of phosphate metabolic process | mammary gland epithelium development | regulation of ion transmembrane transport | establishment of protein localization | T cell homeostasis | response to interleukin-18 | regulation of JNK cascade | positive regulation of endothelial cell migration | response to epidermal growth factor | regulation of reactive oxygen species biosynthetic process | regulation of peptidyl-serine phosphorylation | negative regulation of protein metabolic process | regulation of epithelial cell migration | positive regulation of carbohydrate metabolic process | organonitrogen compound catabolic process | neurotransmitter biosynthetic process | T cell costimulation | response to fluid shear stress | regulation of stress-activated MAPK cascade | regulation of cell communication | regulation of blood vessel endothelial cell migration | negative regulation of molecular function | negative regulation of signal transduction | positive regulation of developmental growth | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of growth | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | regulation of protein binding | glial cell development | response to organic cyclic compound | cell development | regulation of ERBB signaling pathway | energy reserve metabolic process | regulation of developmental growth | I-kappaB kinase/NF-kappaB signaling | protein localization | regulation of epithelial cell proliferation | organic acid metabolic process | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cell size | enzyme regulator activity | positive regulation of epidermal growth factor receptor signaling pathway | negative regulation of plasma membrane long-chain fatty acid transport | regulation of endopeptidase activity | cellular macromolecule localization | cellular macromolecule biosynthetic process | positive regulation of fat cell differentiation | protein serine/threonine/tyrosine kinase activity | regulation of organ growth | response to biotic stimulus | nucleocytoplasmic transport | reproductive structure development | regulation of cellular ketone metabolic process | regulation of nervous system development | regulation of developmental process | regulation of ion transport | positive regulation of DNA metabolic process | energy derivation by oxidation of organic compounds | kinase activity | developmental process | organelle organization | nitric oxide metabolic process | cellular glucan metabolic process | regulation of cell growth | peptidyl-serine phosphorylation | cellular protein modification process | carbohydrate derivative metabolic process | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | regulation of cell-cell adhesion | regulation of fatty acid transport | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | regulation of glycogen biosynthetic process | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | NIK/NF-kappaB signaling | negative regulation of hydrolase activity | regulation of anion transport | positive regulation of nitric oxide biosynthetic process | mammary gland epithelial cell differentiation | central nervous system development | spinal cord development | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of generation of precursor metabolites and energy | in utero embryonic development | regulation of lipid metabolic process | positive regulation of metabolic process | ossification | osteoblast differentiation | positive regulation of lipid metabolic process | regulation of cell projection organization | immune system process | negative regulation of Notch signaling pathway | cellular metabolic process | positive regulation of endodeoxyribonuclease activity | placenta development | response to tumor necrosis factor | negative regulation of fatty acid beta-oxidation | cellular response to organic substance | regulation of protein localization | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of cell motility | regulation of translation | spongiotrophoblast layer development | response to food | negative regulation of cell death | circulatory system development | aging | carbohydrate homeostasis | regulation of ubiquitin-dependent protein catabolic process | sexual reproduction | positive regulation of leukocyte cell-cell adhesion | positive regulation of mitochondrial membrane potential | regulation of I-kappaB kinase/NF-kappaB signaling | regulation of cellular component organization | myelination in peripheral nervous system | response to other organism | positive regulation of signaling | negative regulation of fatty acid metabolic process | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | positive regulation of gene expression | regulation of glycogen metabolic process | cellular response to growth factor stimulus | glycosaminoglycan metabolic process | cellular response to lipopolysaccharide | macromolecule metabolic process | maintenance of location in cell | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | synapse | microtubule organizing center | cell | nuclear lumen | cytoplasm | spindle | intracellular organelle | cell-cell junction | protein-containing complex | cell projection | postsynapse | nucleoplasm | plasma membrane | cilium | vesicle | microtubule cytoskeleton | mitochondrion | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular | cell junction | membrane | ciliary basal body
