QuickView for ALK;jsessionid=E10958033198F1D4407FD5100F9BBB26 (gene)
- Gene Symbol:
- ALK
Homo sapiens - Full name:
- ALK receptor tyrosine kinase
- Synonyms:
- CD246, NBLST3, ALK tyrosine kinase receptor, CD246 antigen, anaplastic lymphoma receptor tyrosine kinase, mutant anaplastic lymphoma kinase
- Genomic Location:
- Chr 2: 29269144-29997936
- Description:
-
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
2p23.2-p23.1
GO Molecular Function
transmembrane receptor protein tyrosine kinase activity | transmembrane signaling receptor activity | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | molecular function regulator | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | signaling receptor activity | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | drug binding | kinase activity | NF-kappaB-inducing kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
regulation of ERK1 and ERK2 cascade | brain development | intracellular signal transduction | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | peptidyl-amino acid modification | transmembrane receptor protein tyrosine kinase activity | hippocampus development | negative regulation of cellular process | regulation of MAP kinase activity | cell differentiation | nervous system development | neurogenesis | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | generation of neurons | cellular process | negative regulation of signaling | neuron development | positive regulation of protein kinase activity | negative regulation of apoptotic process | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | swimming behavior | head development | response to stimulus | positive regulation of protein metabolic process | regulation of cell proliferation | positive regulation of protein serine/threonine kinase activity | protein modification process | macromolecule modification | activation of protein kinase activity | molecular function regulator | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | telencephalon development | regulation of gene expression | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of dopamine receptor signaling pathway | protein autophosphorylation | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | positive regulation of intracellular signal transduction | cell proliferation | locomotory behavior | regulation of cellular protein metabolic process | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | limbic system development | regulation of protein phosphorylation | regulation of RNA metabolic process | protein tyrosine kinase activity | positive regulation of molecular function | neuron differentiation | activation of MAPK activity | protein metabolic process | positive regulation of protein modification process | response to environmental enrichment | regulation of kinase activity | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | behavior | protein kinase activity | organic substance metabolic process | animal organ development | forebrain development | pallium development | positive regulation of NF-kappaB transcription factor activity | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | regulation of phosphate metabolic process | positive regulation of MAPK cascade | adult behavior | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | cell development | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | positive regulation of MAP kinase activity | regulation of G-protein coupled receptor protein signaling pathway | kinase activity | developmental process | cellular protein modification process | NF-kappaB-inducing kinase activity | NIK/NF-kappaB signaling | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | negative regulation of cell death | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | cell | intrinsic component of membrane | cytoplasm | receptor complex | protein-containing complex | plasma membrane | vesicle | extracellular exosome | integral component of plasma membrane | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | intracellular | membrane | intrinsic component of plasma membrane
