QuickView for ALKBH3 (gene)
- Gene Symbol:
- ALKBH3
Homo sapiens - Full name:
- alkB homolog 3, alpha-ketoglutaratedependent dioxygenase
- Synonyms:
- ABH3, DEPC-1, DEPC1, PCA1, hABH3, alpha-ketoglutarate-dependent dioxygenase alkB homolog 3, alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase, alkB, alkylation repair homolog 3, alkylated DNA repair protein alkB homolog 3, prostate cancer antigen-1
- Genomic Location:
- Chr 11: 43858971-43898389
- Description:
-
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
11p11.2
GO Molecular Function
oxidative RNA demethylase activity | cofactor binding | cytosine C-5 DNA demethylase activity | cation binding | L-ascorbic acid binding | carboxylic acid binding | ferrous iron binding | vitamin binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | DNA-N1-methyladenine dioxygenase activity | iron ion binding | RNA N1-methyladenosine dioxygenase activity | coenzyme binding | hydrolase activity | demethylase activity | monosaccharide binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | anion binding | ion binding | carbohydrate binding | protein binding | dioxygenase activity | transition metal ion binding | organic acid binding | metal ion binding | oxidoreductase activity | small molecule binding
GO Biological Process
RNA metabolic process | oxidative RNA demethylase activity | DNA modification | cytosine C-5 DNA demethylase activity | oxidative DNA demethylation | cellular process | oxidative single-stranded DNA demethylation | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | DNA-N1-methyladenine dioxygenase activity | RNA modification | response to stimulus | RNA N1-methyladenosine dioxygenase activity | response to stress | demethylase activity | cellular nitrogen compound metabolic process | macromolecule modification | DNA repair | nitrogen compound metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | cellular response to DNA damage stimulus | cellular response to stress | cell proliferation | DNA demethylation | oxidative demethylation | oxidative RNA demethylation | DNA metabolic process | metabolic process | oxidation-reduction process | nucleobase-containing compound metabolic process | organic substance metabolic process | dioxygenase activity | DNA dealkylation involved in DNA repair | heterocycle metabolic process | demethylation | cellular metabolic process | oxidative single-stranded RNA demethylation | oxidoreductase activity | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | mitochondrion | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
