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QuickView for AMD 3100 (compound)
PubChem
| Name: | JM 3100 |
|---|---|
| PubChem Compound ID: | 65014 |
| Molecular formula: | C28H62Cl8N8 |
| Molecular weight: | 794.467 g/mol |
| Synonyms: |
1,1'-(1,4-Phenylenebis(methylene))bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride; Bicyclam; 1,1'-(1,4-Phenylenebis-(methylene))-bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride dihydrate; AMD-3100; Amd 3100; JM 3100; SDZ-SID-791; 155148-31-5; JM-3100; 1,4,8,11-Tetraazacyclotetradecane, 1,1'-(1,4-phenylenebis(methylene))bis-, octahydrochloride.
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DrugBank
Identification
| Name: | JM 3100 |
|---|---|
| Name (isomeric): | DB06809 |
| Drug Type: | small molecule |
| Synonyms: |
AMD3100
|
| Brand: | Mozobil |
| CAS number: | 110078-46-1 |
Pharmacology
| Indication: | Used in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin’s lymphoma (NHL) and multiple myeloma (MM). |
|---|---|
| Pharmacology: | Plerixafor increases circulating CD34+ cells in the peripheral blood, with a peak effect about 6-9 hours. |
| Mechanism of Action: | Plerixafor inhibits the CXCR4 chemokine receptor and blocks binding to the marrow compartment of its cognate ligand, SDF-1alpha, which play a role in the trafficking and homing of human hematopoietic stem cells. |
| Absorption: | Plerixafor is rapidly absorbed after subcutaneous injection (Tmax = 30-60 min). |
| Protein binding: | Plerixafor is bound to human plasma proteins up to 58%. |
| Route of elimination: | Approximately 70% of the parent drug is excreted in urine during first 24 h. |
| Half Life: | Terminal half-life ranges from 3 to 5 hours. |
Targets
