QuickView for AMFR;jsessionid=5AF227365818A7BACC2E502D0A8408D7 (gene)

Gene Symbol:

AMFR Homo sapiens

Full name:

autocrine motility factor receptor

Synonyms:

GP78, RNF45, E3 ubiquitin-protein ligase AMFR, RING finger protein 45, RING-type E3 ubiquitin transferase AMFR

Genomic Location:

Chr 16: 54952865-55016945

Description:

This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins.

This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTATTAT_MIR3693P ,  RYTTCCTG_ETS2_B ,  GATA_Q6 ,  ATGCTGG_MIR338 ,  LMO2COM_02 ,  SOX5_01 ,  TAATTA_CHX10_01 ,  AACATTC_MIR4093P ,  TTGTTT_FOXO4_01 ,  AP2REP_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  YNGTTNNNATT_UNKNOWN ,  PAX4_01 ,  CTCCAAG_MIR432

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-203

Cytogenetic Map:

16q13

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