QuickView for ANAPC10;jsessionid=E67F4C55E6E512A8622682D946C6AAEB (gene)

Gene Symbol:

ANAPC10 Homo sapiens

Full name:

anaphase promoting complex subunit 10

Synonyms:

APC10, DOC1, anaphase-promoting complex subunit 10, cyclosome subunit 10

Genomic Location:

Chr 4: 146135760-146238818

Description:

ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123...

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ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  CREBP1CJUN_01 ,  CREB_Q4_01 ,  MYCMAX_B ,  CREB_Q3 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  ATF3_Q6 ,  YGCGYRCGC_UNKNOWN ,  YY1_02 ,  GKCGCNNNNNNNTGAYG_UNKNOWN ,  TGACGTCA_ATF3_Q6 ,  E2F1_Q3 ,  CAGCTG_AP4_Q5 ,  CREB_01

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Cytogenetic Map:

4q31.21

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