QuickView for ANGPT2;jsessionid=7D1D703D6C2B949600F429147F686899 (gene)

Gene Symbol:

ANGPT2 Homo sapiens

Full name:

angiopoietin 2

Synonyms:

AGPT2, ANG2, angiopoietin-2, ANG-2, Tie2-ligand, angiopoietin-2B, angiopoietin-2a

Genomic Location:

Chr 8: 6347601-6408170

Description:

The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.

The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PAX4_04 ,  CEBPA_01 ,  GATA1_03 ,  RYTTCCTG_ETS2_B ,  P53_DECAMER_Q2 ,  GATA_C ,  YTATTTTNR_MEF2_02 ,  CACGTG_MYC_Q2 ,  AAAYWAACM_HFH4_01 ,  AACTGGA_MIR145 ,  GATAAGR_GATA_C ,  MYCMAX_02 ,  YYCATTCAWW_UNKNOWN ,  CEBP_01 ,  FREAC3_01 ,  PXR_Q2 ,  GGGCGGR_SP1_Q6 ,  GATA6_01 ,  NKX61_01 ,  NMYC_01 ,  TTGTTT_FOXO4_01 ,  GATA1_05 ,  RGAGGAARY_PU1_Q6 ,  CTGCAGY_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  AACTTT_UNKNOWN ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

8p23.1

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