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QuickView for ANO6;jsessionid=DA737163F65AF93DBCE0E9AFAE2B449B (gene)


Gene Symbol:
ANO6 Homo sapiens Homo sapiens
Full name:
anoctamin 6
Synonyms:
BDPLT7, SCTS, TMEM16F, anoctamin-6, SCAN channel, small-conductance calcium-activated nonselective cation channel, transmembrane protein 16F
Genomic Location:
Chr 12: 43896170-44112399
Description:
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserin...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 12
12q12





GO Molecular Function

anion transmembrane transporter activity | phospholipid scramblase activity | voltage-gated ion channel activity | passive transmembrane transporter activity | voltage-gated anion channel activity | transmembrane transporter activity | ion gated channel activity | chloride channel activity | intracellular calcium activated chloride channel activity | inorganic anion transmembrane transporter activity | chloride transmembrane transporter activity | phospholipid transporter activity | cation transmembrane transporter activity | transporter activity | identical protein binding | ion transmembrane transporter activity | protein binding | protein homodimerization activity | protein dimerization activity | anion channel activity | cation channel activity | inorganic cation transmembrane transporter activity | voltage-gated channel activity | channel activity | calcium activated cation channel activity | ion channel activity | lipid transporter activity | voltage-gated chloride channel activity | substrate-specific channel activity

GO Biological Process

regulation of leukocyte chemotaxis | positive regulation of locomotion | exocytosis | positive regulation of cellular component organization | cell motility | neutrophil activation | positive regulation of apoptotic process | regulation of localization | lipid transport | regulation of programmed cell death | establishment of localization | regulation of immune system process | anion transmembrane transporter activity | positive regulation of developmental process | bone development | bone mineralization | purinergic nucleotide receptor signaling pathway | phospholipid scramblase activity | defense response | positive regulation of biomineral tissue development | regulation of phagocytosis, engulfment | positive regulation of cellular component movement | voltage-gated ion channel activity | membrane organization | cellular process | secretion | leukocyte degranulation | regulation of cell motility | localization | cellular homeostasis | calcium activated phosphatidylserine scrambling | passive transmembrane transporter activity | metal ion transport | positive regulation of blood coagulation | anion transport | macromolecule localization | hemostasis | regulation of chemotaxis | endomembrane system organization | regulation of monocyte chemotaxis | negative regulation of cell volume | voltage-gated anion channel activity | positive regulation of epithelial cell apoptotic process | regulation of membrane lipid distribution | regulation of bone mineralization | tissue development | regulation of cellular process | leukocyte activation | regulation of apoptotic process | transmembrane transporter activity | cellular component organization | positive regulation of potassium ion transport | chloride transmembrane transport | response to stimulus | ion gated channel activity | neutrophil degranulation | positive regulation of immune system process | response to stress | positive regulation of cation transmembrane transport | leukocyte activation involved in immune response | positive regulation of phagocytosis, engulfment | chloride channel activity | chloride transport | inorganic anion transport | positive regulation of endothelial cell apoptotic process | divalent metal ion transport | activation of blood coagulation via clotting cascade | secretion by cell | intracellular calcium activated chloride channel activity | regulation of phagocytosis | regulation of cellular component size | dendritic cell migration | cellular component assembly | regulation of wound healing | inorganic anion transmembrane transporter activity | cell chemotaxis | leukocyte migration | blood coagulation | regulation of potassium ion transmembrane transport | locomotion | system development | positive regulation of response to wounding | positive regulation of monocyte chemotaxis | multicellular organism development | cell migration | chloride transmembrane transporter activity | calcium ion transmembrane transport | phospholipid transporter activity | leukocyte mediated immunity | ion transmembrane transport | regulation of ossification | plasma membrane organization | wound healing | calcium activated galactosylceramide scrambling | positive regulation of chemotaxis | organic substance transport | sodium ion transport | cation transmembrane transporter activity | cell projection assembly | monovalent inorganic cation transport | positive regulation of ion transmembrane transport | regulation of blood coagulation | regulation of cell migration | dendritic cell chemotaxis | vesicle-mediated transport | regulation of cellular component movement | regulation of endothelial cell apoptotic process | ion transmembrane transporter activity | positive regulation of cell migration | positive regulation of ossification | organic anion transport | regulated exocytosis | positive regulation of potassium ion export | pore complex assembly | regulation of epithelial cell apoptotic process | regulation of leukocyte migration | cell communication | positive regulation of leukocyte chemotaxis | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | leukocyte chemotaxis | homeostatic process | regulation of locomotion | positive regulation of transport | ossification involved in bone maturation | coagulation | regulation of potassium ion transport | cation transmembrane transport | phospholipid transport | protein-containing complex assembly | positive regulation of potassium ion transmembrane transport | response to wounding | positive regulation of mononuclear cell migration | anion transmembrane transport | anatomical structure development | cell surface receptor signaling pathway | cell projection organization | lipid localization | anion channel activity | developmental maturation | regulation of body fluid levels | positive regulation of coagulation | regulation of vesicle-mediated transport | calcium ion transport | positive regulation of cell death | immune response | sodium ion transmembrane transport | phospholipid scrambling | animal organ development | positive regulation of ion transport | calcium activated phospholipid scrambling | positive regulation of leukocyte migration | positive regulation of programmed cell death | positive regulation of phagocytosis | biomineral tissue development | positive regulation of wound healing | inorganic cation transmembrane transport | regulation of ion transmembrane transport | cell activation | cation channel activity | bone maturation | regulation of response to wounding | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | regulation of endocytosis | calcium activated phosphatidylcholine scrambling | voltage-gated channel activity | regulation of cell size | cation transport | channel activity | bleb assembly | regulation of developmental process | regulation of ion transport | calcium activated cation channel activity | developmental process | regulation of transport | neutrophil mediated immunity | ion channel activity | ossification | lipid transporter activity | ion transport | acute inflammatory response | skeletal system development | immune system process | regulation of cell death | positive regulation of cell motility | bone mineralization involved in bone maturation | voltage-gated chloride channel activity | chemotaxis | substrate-specific channel activity | positive regulation of endocytosis | regulation of cellular component organization | positive regulation of bone mineralization | cell volume homeostasis | phosphatidylserine exposure on blood platelet | signal transduction | multicellular organismal process

GO Cellular Component

secretory granule | integral component of membrane | organelle membrane | tertiary granule | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | secretory granule membrane | protein-containing complex | secretory vesicle | endomembrane system | plasma membrane | chloride channel complex | vesicle | extracellular exosome | specific granule | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | vesicle membrane | extracellular space | cell periphery | transmembrane transporter complex | tertiary granule membrane | ion channel complex | cytosol | intracellular vesicle | cell surface | intracellular | specific granule membrane | membrane | cytoplasmic vesicle membrane