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QuickView for ANX2 (gene)


Gene Symbol:
ANXA2 Homo sapiens Homo sapiens
Full name:
annexin A2
Synonyms:
ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV, annexin A2, annexin II, annexin-2, calpactin I heavy chain, calpactin I heavy polypeptide, calpactin-1 heavy chain, chromobindin 8, epididymis secretory protein Li 270, lipocortin II, placental anticoagulant protein IV, protein I
Genomic Location:
Chr 15: 58426642-58477477
Description:
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located ...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 15
15q22.2





GO Molecular Function

GTPase binding | phosphatidylinositol-4,5-bisphosphate binding | voltage-gated ion channel activity | modified amino acid binding | cadherin binding | cation binding | phospholipase A2 inhibitor activity | S100 protein binding | passive transmembrane transporter activity | cadherin binding involved in cell-cell adhesion | enzyme binding | nucleic acid binding | cell-cell adhesion mediator activity | transmembrane transporter activity | lipid binding | enzyme inhibitor activity | ion gated channel activity | phospholipid binding | Ras GTPase binding | molecular function regulator | voltage-gated calcium channel activity | bone sialoprotein binding | extracellular matrix binding | cytoskeletal protein binding | anion binding | phosphatidylinositol bisphosphate binding | cation transmembrane transporter activity | lipase inhibitor activity | transporter activity | calcium-dependent protein binding | calcium ion transmembrane transporter activity | identical protein binding | ion transmembrane transporter activity | ion binding | organic cyclic compound binding | cell adhesion molecule binding | protein binding | virion binding | phosphatidylserine binding | metal ion transmembrane transporter activity | voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels | voltage-gated cation channel activity | phosphatidylinositol binding | small GTPase binding | Rab GTPase binding | cation channel activity | calcium ion binding | cell adhesion mediator activity | phospholipase inhibitor activity | inorganic cation transmembrane transporter activity | voltage-gated channel activity | enzyme regulator activity | channel activity | protease binding | calcium channel activity | calcium-dependent phospholipid binding | metal ion binding | ion channel activity | heterocyclic compound binding | substrate-specific channel activity | phosphatidylinositol phosphate binding | RNA binding

GO Biological Process

exocytosis | protein heterotetramerization | extracellular structure organization | response to cytokine | positive regulation of cellular component organization | neutrophil activation | protein localization to cell periphery | regulation of cellular localization | regulation of cholesterol transport | regulation of vacuole organization | regulation of localization | negative regulation of low-density lipoprotein particle receptor catabolic process | establishment of localization | negative regulation of development of symbiont involved in interaction with host | response to hormone | myeloid cell differentiation | negative regulation of cellular process | positive regulation of developmental process | bone development | cell differentiation | regulation of intracellular cholesterol transport | positive regulation of fibroblast proliferation | endothelial cell differentiation | positive regulation of receptor recycling | organ growth | cellular chemical homeostasis | endochondral bone morphogenesis | positive regulation of phosphate metabolic process | regulation of organelle organization | voltage-gated ion channel activity | membrane organization | membrane biogenesis | positive regulation of viral life cycle | regulation of lipid transport | interaction with symbiont | blood vessel morphogenesis | cellular process | secretion | organic substance catabolic process | leukocyte degranulation | positive regulation of cartilage development | phospholipase A2 inhibitor activity | localization | cellular homeostasis | catabolism by host of symbiont protein | passive transmembrane transporter activity | metal ion transport | developmental growth | cadherin binding involved in cell-cell adhesion | immune system development | macromolecule localization | regulation of proteolysis | positive regulation of nitrogen compound metabolic process | myeloid cell development | growth plate cartilage development | negative regulation of cellular metabolic process | positive regulation of chondrocyte differentiation | tissue development | regulation of binding | regulation of cell differentiation | interspecies interaction between organisms | negative regulation of wound healing | regulation of cellular process | leukocyte activation | positive regulation of vesicle fusion | regulation of metabolic process | catabolic process | regulation of cytosolic calcium ion concentration | cell-cell adhesion mediator activity | transmembrane transporter activity | regulation of intracellular lipid transport | positive regulation of cellular protein metabolic process | epithelium development | cellular component organization | calcium ion homeostasis | negative regulation of cellular protein catabolic process | positive regulation of protein binding | response to stimulus | enzyme inhibitor activity | ion gated channel activity | vasculature development | membrane raft assembly | neutrophil degranulation | positive regulation of protein metabolic process | regulation of plasminogen activation | regulation of cellular protein catabolic process | leukocyte activation involved in immune response | regulation of cell proliferation | tube morphogenesis | cartilage development involved in endochondral bone morphogenesis | supramolecular fiber organization | cellular localization | divalent metal ion transport | secretion by cell | cardiovascular system development | extracellular matrix organization | negative regulation of metabolic process | hemopoiesis | cellular component assembly | regulation of wound healing | endocardial cell differentiation | regulation of protein processing | cartilage development | membrane raft organization | response to interleukin-12 | interleukin-12-mediated signaling pathway | regulation of intracellular transport | molecular function regulator | metal ion homeostasis | blood vessel development | voltage-gated calcium channel activity | leukocyte differentiation | system development | nitrogen compound metabolic process | positive regulation of organelle organization | endothelium development | regulation of cartilage development | positive regulation of viral process | multicellular organism development | negative regulation of catalytic activity | calcium ion transmembrane transport | protein complex oligomerization | leukocyte mediated immunity | regulation of catalytic activity | regulation of phosphorylation | ion transmembrane transport | protein localization to plasma membrane | regulation of receptor-mediated endocytosis | positive regulation of receptor-mediated endocytosis | modulation by host of viral process | regulation of gene expression | osteoclast differentiation | protein localization to membrane | protein catabolic process | membrane assembly | cation transmembrane transporter activity | myeloid leukocyte differentiation | modification of morphology or physiology of other organism | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | animal organ morphogenesis | regulation of blood coagulation | regulation of nitrogen compound metabolic process | positive regulation of lipoprotein particle clearance | cytokine-mediated signaling pathway | bone growth | cardiocyte differentiation | lipase inhibitor activity | vesicle-mediated transport | positive regulation by host of viral process | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | positive regulation of vacuole organization | positive regulation of cell differentiation | positive regulation of cholesterol transport | cellular response to cytokine stimulus | negative regulation of receptor catabolic process | regulation of cellular protein metabolic process | angiogenesis | regulated exocytosis | protein tetramerization | positive regulation of lipid localization | cation homeostasis | fibrinolysis | positive regulation of intracellular cholesterol transport | negative regulation of response to wounding | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | skeletal system morphogenesis | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | neutrophil activation involved in immune response | heart development | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | bone morphogenesis | positive regulation of transport | regulation of vesicle fusion | regulation of viral process | positive regulation of molecular function | cation transmembrane transport | protein-containing complex assembly | negative regulation by host of symbiont molecular function | protein metabolic process | regulation of fibroblast proliferation | positive regulation of protein modification process | response to organic substance | endocardium development | metal ion transmembrane transporter activity | voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels | anatomical structure development | cell surface receptor signaling pathway | voltage-gated cation channel activity | metabolic process | regulation of protein catabolic process | regulation of body fluid levels | cellular protein localization | positive regulation of receptor-mediated endocytosis involved in cholesterol transport | regulation of vesicle-mediated transport | chemical homeostasis | calcium ion transport | body fluid secretion | cell adhesion | immune response | regulation of chondrocyte differentiation | organic substance metabolic process | connective tissue development | animal organ development | positive regulation of ion transport | negative regulation of cellular protein metabolic process | regulation of low-density lipoprotein particle receptor catabolic process | ion homeostasis | osteoclast development | regulation of phosphate metabolic process | biomineral tissue development | inorganic cation transmembrane transport | positive regulation of binding | vesicle organization | cell-cell adhesion | positive regulation of intracellular transport | vesicle budding from membrane | cell activation | cation channel activity | anatomical structure formation involved in morphogenesis | negative regulation of protein catabolic process | negative regulation of protein metabolic process | organonitrogen compound catabolic process | regulation of response to wounding | positive regulation of low-density lipoprotein particle receptor binding | cell adhesion mediator activity | phospholipase inhibitor activity | negative regulation of molecular function | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | regulation of protein binding | cell development | regulation of endocytosis | positive regulation of low-density lipoprotein particle clearance | collagen fibril organization | protein localization | positive regulation of phosphorylation | voltage-gated channel activity | enzyme regulator activity | protein heterooligomerization | anatomical structure morphogenesis | cation transport | cellular macromolecule localization | channel activity | positive regulation of receptor binding | regulation of developmental process | regulation of ion transport | developmental process | organelle organization | calcium channel activity | regulation of calcium ion transport | response to thyroid hormone | negative regulation of coagulation | tube development | regulation of transport | regulation of receptor recycling | neutrophil mediated immunity | cellular metal ion homeostasis | epithelial cell differentiation | regulation of low-density lipoprotein particle clearance | negative regulation of blood coagulation | ion channel activity | positive regulation of metabolic process | ion transport | skeletal system development | positive regulation of lipid transport | immune system process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of viral life cycle | circulatory system development | endochondral bone growth | divalent inorganic cation homeostasis | substrate-specific channel activity | positive regulation of endocytosis | regulation of cellular component organization | positive regulation of calcium ion transport | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of low-density lipoprotein receptor activity | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | azurophil granule lumen | myelin sheath adaxonal region | intracellular membrane-bounded organelle | sarcolemma | late endosome | extrinsic component of membrane | extracellular matrix | ruffle | basement membrane | adherens junction | organelle membrane | macropinosome | cytoplasmic vesicle | cell | late endosome membrane | extrinsic component of plasma membrane | vacuolar lumen | compact myelin | cytoplasmic vesicle lumen | cytoplasm | collagen-containing extracellular matrix | intracellular organelle | membrane microdomain | cell-cell adherens junction | melanosome | cell-cell junction | endosome membrane | protein-containing complex | cell projection | secretory vesicle | endomembrane system | plasma membrane | midbody | cell leading edge | membrane raft | vacuole | vesicle | lipid droplet | perinuclear region of cytoplasm | extracellular exosome | cytoplasmic region | lytic vacuole | endosome | extracellular region | cell cortex | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | lysosome | extracellular space | cell periphery | membrane-enclosed lumen | azurophil granule | early endosome | basolateral plasma membrane | Schmidt-Lanterman incisure | PCSK9-AnxA2 complex | secretory granule lumen | cytosol | intracellular vesicle | cell surface | intracellular | cell junction | myelin sheath | lysosomal membrane | membrane | vesicle lumen | vacuolar membrane