QuickView for ANXA1 (gene)
- Gene Symbol:
- ANXA1
Homo sapiens - Full name:
- annexin A1
- Synonyms:
- ANX1, LPC1, annexin A1, annexin I (lipocortin I), annexin-1, calpactin II, calpactin-2, chromobindin-9, phospholipase A2 inhibitory protein
- Genomic Location:
- Chr 9: 74956601-74975127
- Description:
-
This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
9q21.13
GO Molecular Function
structural molecule activity | cadherin binding | cation binding | phospholipase A2 inhibitor activity | cadherin binding involved in cell-cell adhesion | nucleic acid binding | cell-cell adhesion mediator activity | lipid binding | double-stranded DNA-dependent ATPase activity | enzyme inhibitor activity | signaling receptor binding | hydrolase activity | single-stranded DNA binding | phospholipid binding | ATPase activity | pyrophosphatase activity | molecular function regulator | catalytic activity | protein binding, bridging | anion binding | single-stranded RNA binding | nucleoside-triphosphatase activity | ATPase activity, coupled | DNA binding | lipase inhibitor activity | calcium-dependent protein binding | identical protein binding | ion binding | organic cyclic compound binding | molecular adaptor activity | cell adhesion molecule binding | protein binding | protein homodimerization activity | protein dimerization activity | hydrolase activity, acting on acid anhydrides | calcium ion binding | cell adhesion mediator activity | phospholipase inhibitor activity | enzyme regulator activity | DNA-dependent ATPase activity | calcium-dependent phospholipid binding | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | DNA/DNA annealing activity | RNA binding
GO Biological Process
positive regulation of immune response | negative regulation of lymphocyte differentiation | leukocyte homeostasis | negative regulation of leukocyte activation | positive regulation of myeloid cell apoptotic process | negative regulation of phospholipase activity | adaptive immune response | long-chain fatty acid transport | response to radiation | regulation of cell cycle process | positive regulation of locomotion | negative regulation of immune system process | actin filament-based process | response to cytokine | response to interleukin-1 | myoblast migration | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | developmental process involved in reproduction | negative regulation of peptide secretion | positive regulation of apoptotic process | regulation of localization | regulation of cell cycle G1/S phase transition | positive regulation of neutrophil apoptotic process | lipid transport | positive regulation of G1/S transition of mitotic cell cycle | regulation of programmed cell death | hormone secretion | negative regulation of lipase activity | response to X-ray | actin cytoskeleton organization | establishment of localization | regulation of immune system process | response to hormone | regulation of cell shape | neutrophil homeostasis | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | positive regulation of developmental process | positive regulation of lymphocyte activation | cell differentiation | regulation of T cell differentiation | defense response | nervous system development | response to drug | regulation of sprouting angiogenesis | regulation of G1/S transition of mitotic cell cycle | neurogenesis | positive regulation of cell adhesion | negative regulation of protein secretion | regulation of organelle organization | positive regulation of cellular component movement | response to antibiotic | positive regulation of T cell differentiation | positive regulation of cellular biosynthetic process | cellular process | secretion | peptide hormone secretion | lymphocyte differentiation | monocarboxylic acid transport | phospholipase A2 inhibitor activity | regulation of cell motility | localization | protein transport | tissue remodeling | developmental growth | positive regulation of immune effector process | reproductive system development | response to estradiol | positive regulation of adaptive immune response | negative regulation of phospholipase A2 activity | cadherin binding involved in cell-cell adhesion | anion transport | immune system development | multicellular organismal reproductive process | negative regulation of alpha-beta T cell differentiation | macromolecule localization | negative regulation of apoptotic process | negative regulation of secretion | regulation of cell cycle | response to growth factor | granulocyte chemotaxis | response to inorganic substance | negative regulation of establishment of protein localization | response to peptide hormone | tissue development | regulation of cell differentiation | negative regulation of CD4-positive, alpha-beta T cell activation | DNA geometric change | positive regulation of unsaturated fatty acid biosynthetic process | regeneration | response to hydrogen peroxide | regulation of angiogenesis | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | cellular response to lipid | positive regulation of vesicle fusion | regulation of metabolic process | gliogenesis | negative regulation of cytokine secretion | hepaticobiliary system development | cell-cell adhesion mediator activity | positive regulation of cell cycle phase transition | regulation of type 2 immune response | epithelium development | endocrine pancreas development | cellular component organization | urogenital system development | positive regulation of epithelial cell migration | T cell activation | regulation of peptide secretion | regulation of vasculature development | response to stimulus | enzyme inhibitor activity | negative regulation of protein transport | acid secretion | cellular response to vascular endothelial growth factor stimulus | regulation of interleukin-8 secretion | regulation of mitotic cell cycle phase transition | regulation of fatty acid biosynthetic process | positive regulation of immune system process | negative regulation of cell adhesion | regulation of CD4-positive, alpha-beta T cell activation | response to stress | negative regulation of lymphocyte activation | positive regulation of lymphocyte proliferation | regulation of cell proliferation | positive regulation of lipid biosynthetic process | ovulation cycle | response to peptide | positive regulation of cell-cell adhesion | regulation of cell cycle phase transition | positive regulation of cell activation | reproduction | secretion by cell | negative regulation of T-helper 2 cell differentiation | positive regulation of sprouting angiogenesis | rhythmic process | cellular response to toxic substance | positive regulation of T cell activation | negative regulation of transport | positive regulation of blood vessel endothelial cell migration | cellular response to organic cyclic compound | regulation of protein transport | G-protein coupled receptor signaling pathway | monocyte chemotaxis | hemopoiesis | regulation of wound healing | negative regulation of hemopoiesis | protein modification process | regulation of peptide transport | peptide cross-linking | regulation of cell adhesion | macromolecule modification | cell-cell signaling | cell chemotaxis | insulin secretion | molecular function regulator | regulation of lymphocyte differentiation | myeloid cell homeostasis | leukocyte migration | leukocyte differentiation | locomotion | response to nitrogen compound | cellular response to hormone stimulus | positive regulation of mononuclear cell proliferation | system development | positive regulation of response to wounding | nitrogen compound metabolic process | reproductive process | positive regulation of organelle organization | negative regulation of secretion by cell | negative regulation of T-helper cell differentiation | cellular response to antibiotic | multicellular organism development | negative regulation of catalytic activity | cell migration | positive regulation of lymphocyte differentiation | regulation of catalytic activity | cellular response to oxidative stress | regulation of hormone levels | regulation of hormone secretion | regulation of CD4-positive, alpha-beta T cell differentiation | wound healing | arachidonic acid secretion | regulation of T cell activation | positive regulation of cell cycle | positive regulation of alpha-beta T cell differentiation | positive regulation of mitotic cell cycle | fatty acid transport | pancreas development | organic substance transport | cellular response to stress | response to lipid | negative regulation of cytokine production | positive regulation of cellular metabolic process | regulation of lymphocyte activation | liver development | negative regulation of T cell activation | regulation of cell migration | peptide transport | cytokine-mediated signaling pathway | lipase inhibitor activity | response to corticosteroid | vesicle-mediated transport | regulation of cellular component movement | alpha-beta T cell differentiation | response to oxidative stress | organic acid transport | regulation of cell migration involved in sprouting angiogenesis | regulation of fatty acid metabolic process | positive regulation of cell differentiation | regulation of endothelial cell migration | epidermal cell differentiation | homeostasis of number of cells | positive regulation of cell migration | cellular response to cytokine stimulus | negative regulation of type 2 immune response | positive regulation of T cell proliferation | negative regulation of immune response | cellular response to glucocorticoid stimulus | hepatocyte differentiation | organic anion transport | regulation of phospholipase activity | positive regulation of fatty acid biosynthetic process | epidermis development | response to toxic substance | positive regulation of leukocyte apoptotic process | skin development | endocrine system development | positive regulation of cell cycle G1/S phase transition | keratinocyte differentiation | cellular response to corticosteroid stimulus | regulation of leukocyte migration | DNA duplex unwinding | cellular response to drug | regulation of interleukin-1 production | negative regulation of cell-cell adhesion | peptide secretion | cell communication | regulation of cellular metabolic process | regulation of alpha-beta T cell differentiation | negative regulation of cell activation | inflammatory response | leukocyte chemotaxis | homeostatic process | positive regulation of cell proliferation | negative regulation of CD4-positive, alpha-beta T cell differentiation | regulation of locomotion | positive regulation of transport | regulation of vesicle fusion | regulation of lipid biosynthetic process | regulation of prostaglandin biosynthetic process | negative regulation of T cell differentiation | regulation of mitotic cell cycle | lymphocyte activation | negative regulation of exocytosis | regulation of cytokine secretion | multicellular organism reproduction | T cell differentiation | protein metabolic process | muscle cell migration | regulation of establishment of protein localization | positive regulation of T-helper cell differentiation | response to organic substance | gland development | regulation of hemopoiesis | response to wounding | import into cell | positive regulation of fatty acid metabolic process | regulation of exocytosis | anatomical structure development | positive regulation of mitotic cell cycle phase transition | cell surface receptor signaling pathway | metabolic process | lipid localization | negative regulation of interleukin-8 secretion | regulation of adaptive immune response | positive regulation of leukocyte activation | negative regulation of programmed cell death | actin cytoskeleton reorganization | amide transport | cellular response to hydrogen peroxide | regulation of vesicle-mediated transport | endocytosis | regulation of secretion | positive regulation of cell death | cell adhesion | regulation of myeloid cell apoptotic process | immune response | hormone transport | cellular response to reactive oxygen species | organic substance metabolic process | positive regulation of T-helper 1 type immune response | positive regulation of T-helper 1 cell differentiation | animal organ development | response to reactive oxygen species | regulation of cell activation | regulation of protein secretion | positive regulation of programmed cell death | alpha-beta T cell activation | positive regulation of wound healing | cytoskeleton organization | cellular response to steroid hormone stimulus | myoblast migration involved in skeletal muscle regeneration | establishment of protein localization | cell-cell adhesion | negative regulation of interleukin-8 production | positive regulation of cytokine production | positive regulation of endothelial cell migration | cell activation | regulation of T-helper cell differentiation | regulation of epithelial cell migration | estrous cycle | skeletal muscle tissue regeneration | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of response to wounding | regulation of cell communication | cell adhesion mediator activity | regulation of blood vessel endothelial cell migration | phospholipase inhibitor activity | regulation of T-helper 1 cell differentiation | negative regulation of molecular function | signaling | response to organic cyclic compound | positive regulation of prostaglandin biosynthetic process | positive regulation of cell migration involved in sprouting angiogenesis | regulation of T cell proliferation | positive regulation of CD4-positive, alpha-beta T cell differentiation | protein localization | regulation of phospholipase A2 activity | cellular protein metabolic process | enzyme regulator activity | carboxylic acid transport | regulation of cytokine production | prostate gland development | reproductive structure development | regulation of cellular ketone metabolic process | regulation of developmental process | developmental process | organelle organization | positive regulation of alpha-beta T cell activation | positive regulation of cell cycle process | cellular protein modification process | negative regulation of alpha-beta T cell activation | positive regulation of interleukin-2 production | regulation of transport | regulation of cell-cell adhesion | innate immune response | signal release | DNA conformation change | response to organonitrogen compound | epithelial cell differentiation | negative regulation of hydrolase activity | prolactin secretion | neutrophil clearance | regulation of lipid metabolic process | positive regulation of metabolic process | chromosome organization | positive regulation of lipid metabolic process | ion transport | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of protein localization | regulation of cell death | protein secretion | positive regulation of cell motility | response to steroid hormone | positive regulation of CD4-positive, alpha-beta T cell activation | negative regulation of cell death | regulation of inflammatory response | chemotaxis | tissue regeneration | phagocytosis | positive regulation of leukocyte cell-cell adhesion | positive regulation of angiogenesis | negative regulation of cell differentiation | regulation of cellular component organization | response to ionizing radiation | signal transduction | mononuclear cell migration | regulation of signaling | response to glucocorticoid | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
supramolecular fiber | intracellular membrane-bounded organelle | early endosome membrane | sarcolemma | extrinsic component of organelle membrane | apical plasma membrane | extrinsic component of membrane | adherens junction | organelle membrane | focal adhesion | cytoplasmic vesicle | cell | nuclear lumen | mast cell granule | extrinsic component of plasma membrane | extrinsic component of endosome membrane | external side of plasma membrane | cytoplasm | cell-substrate junction | intracellular organelle | actin cytoskeleton | motile cilium | apical part of cell | cell-cell adherens junction | cell-cell junction | endosome membrane | cornified envelope | protein-containing complex | cell projection | endomembrane system | nucleoplasm | plasma membrane | cilium | vacuole | vesicle | extracellular exosome | mitochondrion | lytic vacuole | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | phagocytic cup | vesicle membrane | mitochondrial envelope | lysosome | extracellular space | cell periphery | extrinsic component of external side of plasma membrane | membrane-enclosed lumen | early endosome | basolateral plasma membrane | cell-substrate adherens junction | mitochondrial membrane | cytosol | intracellular vesicle | actin filament | cell surface | cytoskeleton | intracellular | cell junction | lateral plasma membrane | membrane | supramolecular complex | cytoplasmic vesicle membrane
