QuickView for APEX2;jsessionid=4F3E745D2C96C6B4BDABA79C73C35308 (gene)

Gene Symbol:

APEX2 Homo sapiens

Full name:

apurinic/apyrimidinic endodeoxyribonuclease 2

Synonyms:

APE2, APEXL2, XTH2, ZGRF2, DNA-(apurinic or apyrimidinic site) lyase 2, AP endonuclease 2, AP endonuclease XTH2, APEX nuclease (apurinic/apyrimidinic endonuclease) 2, apurinic/apyrimidinic endonuclease-like 2, zinc finger, GRF-type containing 2

Genomic Location:

Chr X: 55043505-55050937

Description:

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave t...

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Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HOXA4_Q2 ,  TGACCTY_ERR1_Q2 ,  WTGAAAT_UNKNOWN ,  CEBPDELTA_Q6 ,  ZID_01 ,  COUP_DR1_Q6 ,  RORA2_01 ,  ER_Q6_01 ,  YNGTTNNNATT_UNKNOWN

miRNA binding sites
(Source: miRecords):

hsa-miR-124 Targeted Genes

Cytogenetic Map:

Xp11.21

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