QuickView for APLP1 (gene)

Gene Symbol:

APLP1 Homo sapiens

Full name:

amyloid beta precursor like protein 1

Synonyms:

APLP, amyloid-like protein 1, amyloid beta (A4) precursor-like protein 1, amyloid precursor-like protein 1

Genomic Location:

Chr 19: 41051241-41062539

Description:

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator...

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This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AP2GAMMA_01 ,  AP2ALPHA_01 ,  GCCATNTTG_YY1_Q6 ,  AP2_Q6_01 ,  CTTTAAR_UNKNOWN ,  AP2_Q3 ,  AP2_Q6 ,  SP1_Q6_01

Cytogenetic Map:

19q13.12

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