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QuickView for APOA1;jsessionid=0DEC34922ACD7887AF8D53E702C11070 (gene)


Gene Symbol:
APOA1 Homo sapiens Homo sapiens
Full name:
apolipoprotein A1
Synonyms:
apo(a), apolipoprotein A-I, apo-AI
Genomic Location:
Chr 11: 116211679-116213548
Description:
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Cytogenetic Map:
chr 11
11q23.3





GO Molecular Function

enzyme activator activity | peptide binding | amyloid-beta binding | phosphatidylcholine-sterol O-acyltransferase activator activity | chemorepellent activity | enzyme binding | protein-containing complex binding | lipoprotein particle receptor binding | lipid binding | sterol binding | enzyme inhibitor activity | signaling receptor binding | phospholipid binding | cholesterol transporter activity | alcohol binding | molecular function regulator | lipoprotein particle binding | apolipoprotein A-I receptor binding | phospholipid transporter activity | anion binding | amide binding | lipase inhibitor activity | transporter activity | identical protein binding | high-density lipoprotein particle receptor binding | sterol transporter activity | ion binding | organic cyclic compound binding | cholesterol binding | apolipoprotein receptor binding | high-density lipoprotein particle binding | protein binding | receptor regulator activity | receptor ligand activity | enzyme regulator activity | steroid binding | heat shock protein binding | lipid transporter activity | small molecule binding

GO Biological Process

response to extracellular stimulus | regulation of supramolecular fiber organization | regulation of interleukin-1 beta production | high-density lipoprotein particle clearance | response to nutrient levels | negative regulation of immune system process | exocytosis | positive regulation of Ras protein signal transduction | extracellular structure organization | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | negative regulation of peptide secretion | intracellular signal transduction | regulation of cholesterol transport | enzyme activator activity | regulation of cell development | protein stabilization | regulation of localization | lipid transport | negative regulation of lipase activity | peptidyl-amino acid modification | triglyceride catabolic process | protein oxidation | establishment of localization | blood vessel endothelial cell migration | regulation of immune system process | lipid storage | platelet degranulation | negative regulation of cellular process | integrin-mediated signaling pathway | positive regulation of developmental process | cell differentiation | nervous system development | response to drug | epithelial cell migration | protein-lipid complex assembly | neurogenesis | positive regulation of cell adhesion | negative regulation of protein secretion | regulation of organelle organization | generation of neurons | phospholipid metabolic process | regulation of lipid transport | sterol metabolic process | cellular process | secretion | organic substance catabolic process | negative regulation of inflammatory response | localization | phosphatidylcholine-sterol O-acyltransferase activator activity | negative regulation of signaling | neuron development | anion homeostasis | epithelium migration | triglyceride metabolic process | regulation of embryonic development | chemorepellent activity | anion transport | negative regulation of tumor necrosis factor-mediated signaling pathway | macromolecule localization | regulation of response to cytokine stimulus | negative regulation of secretion | acylglycerol catabolic process | response to growth factor | positive regulation of catalytic activity | endothelial cell proliferation | negative regulation of establishment of protein localization | regulation of cell differentiation | regeneration | regulation of immune response | regulation of cellular process | negative regulation of interleukin-1 production | regulation of metabolic process | negative regulation of cytokine secretion | catabolic process | negative regulation of cell adhesion molecule production | organic cyclic compound metabolic process | steroid biosynthetic process | cellular component organization | cellular lipid metabolic process | MAPK cascade | response to transforming growth factor beta | peptidyl-methionine modification | regulation of peptide secretion | response to stimulus | enzyme inhibitor activity | negative regulation of protein transport | signal transduction by protein phosphorylation | negative regulation of cell adhesion | response to stress | regulation of heterotypic cell-cell adhesion | endothelial cell migration | cholesterol import | phosphatidylcholine biosynthetic process | chylomicron assembly | alcohol metabolic process | positive regulation of lipid biosynthetic process | positive regulation of actin filament bundle assembly | regulation of plasma lipoprotein particle levels | sterol homeostasis | cholesterol homeostasis | lipoprotein biosynthetic process | secretion by cell | organic hydroxy compound transport | regulation of cholesterol esterification | cholesterol transporter activity | negative regulation of transport | regulation of protein transport | G-protein coupled receptor signaling pathway | cellular component assembly | protein modification process | regulation of peptide transport | regulation of cell adhesion | cellular biosynthetic process | macromolecule modification | regulation of steroid metabolic process | molecular function regulator | positive regulation of stress fiber assembly | locomotion | organic hydroxy compound metabolic process | retinoid metabolic process | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of secretion by cell | regulation of protein stability | regulation of actin cytoskeleton organization | multicellular organism development | negative regulation of catalytic activity | cell migration | phosphorus metabolic process | regulation of actin filament organization | phospholipid transporter activity | regulation of catalytic activity | vitamin transport | lipid metabolic process | regulation of actomyosin structure organization | regulation of phosphorylation | regulation of hormone levels | regulation of small GTPase mediated signal transduction | axon development | organic substance transport | cellular response to stress | organophosphate metabolic process | negative regulation of cytokine production | positive regulation of cellular metabolic process | response to axon injury | sterol biosynthetic process | phospholipid biosynthetic process | positive regulation of Rho protein signal transduction | regulation of nitrogen compound metabolic process | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | small molecule metabolic process | positive regulation of intracellular signal transduction | lipase inhibitor activity | vesicle-mediated transport | response to nutrient | positive regulation of hydrolase activity | negative regulation of heterotypic cell-cell adhesion | positive regulation of cell differentiation | positive regulation of steroid metabolic process | regulation of Rho protein signal transduction | cell proliferation | biosynthetic process | sterol transporter activity | sterol transport | plasma lipoprotein particle assembly | neuron projection regeneration | cholesterol biosynthetic process | regulation of cellular protein metabolic process | negative regulation of immune response | organic anion transport | phosphorylation | regulated exocytosis | triglyceride homeostasis | lipid biosynthetic process | negative regulation of interleukin-1 secretion | cholesterol transport | cholesterol efflux | endocrine system development | protein phosphorylation | plasma lipoprotein particle clearance | phosphate-containing compound metabolic process | very-low-density lipoprotein particle remodeling | regulation of interleukin-1 production | response to estrogen | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | cellular lipid catabolic process | phospholipid homeostasis | lipoprotein metabolic process | regulation of tumor necrosis factor-mediated signaling pathway | positive regulation of cytoskeleton organization | regulation of cytokine production involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cholesterol esterification | peripheral nervous system axon regeneration | homeostatic process | regulation of protein phosphorylation | reverse cholesterol transport | plasma lipoprotein particle remodeling | regulation of cytokine-mediated signaling pathway | glycerolipid metabolic process | regulation of lipid biosynthetic process | neutral lipid catabolic process | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | regulation of cytokine secretion | neuron differentiation | phospholipid transport | regulation of signaling receptor activity | receptor regulator activity | protein-containing complex assembly | regulation of cell morphogenesis involved in differentiation | protein metabolic process | regulation of establishment of protein localization | response to organic substance | gland development | regulation of Cdc42 protein signal transduction | neutral lipid metabolic process | glycerophospholipid biosynthetic process | epithelial cell proliferation | response to wounding | import into cell | regulation of intracellular signal transduction | chylomicron remodeling | phospholipid efflux | anatomical structure development | cell surface receptor signaling pathway | negative regulation of response to cytokine stimulus | positive regulation of small GTPase mediated signal transduction | cell projection organization | metabolic process | lipid localization | positive regulation of cell development | positive regulation of supramolecular fiber organization | regulation of interleukin-1 beta secretion | cholesterol metabolic process | oxidation-reduction process | regulation of cytokine secretion involved in immune response | high-density lipoprotein particle remodeling | adrenal gland development | regulation of cell-cell adhesion involved in gastrulation | chemical homeostasis | endocytosis | regulation of secretion | receptor ligand activity | neuron projection development | lipid catabolic process | positive regulation of cellular component biogenesis | organic substance metabolic process | animal organ development | positive regulation of cell-substrate adhesion | regulation of protein secretion | phosphatidylcholine metabolic process | diterpenoid metabolic process | ion homeostasis | regulation of phosphate metabolic process | negative regulation of very-low-density lipoprotein particle remodeling | transforming growth factor beta receptor signaling pathway | regulation of stress fiber assembly | steroid metabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | glucocorticoid metabolic process | cell development | cellular protein metabolic process | enzyme regulator activity | regulation of cytokine production | hormone metabolic process | regulation of Ras protein signal transduction | high-density lipoprotein particle assembly | cellular macromolecule biosynthetic process | regulation of actin filament bundle assembly | axon regeneration | isoprenoid metabolic process | regulation of developmental process | receptor-mediated endocytosis | glycerophospholipid metabolic process | negative regulation of interleukin-1 beta secretion | developmental process | cellular protein modification process | acylglycerol homeostasis | negative regulation of cytokine secretion involved in immune response | negative regulation of interleukin-1 beta production | negative chemotaxis | regulation of gastrulation | regulation of transport | protein-lipid complex remodeling | regulation of cell-cell adhesion | ERK1 and ERK2 cascade | negative regulation of cytokine-mediated signaling pathway | negative regulation of hydrolase activity | regulation of lipid metabolic process | triglyceride-rich lipoprotein particle remodeling | positive regulation of metabolic process | regulation of actin filament-based process | lipid transporter activity | positive regulation of lipid metabolic process | ion transport | sterol import | cellular metabolic process | ameboidal-type cell migration | cellular response to organic substance | regulation of protein localization | regulation of substrate adhesion-dependent cell spreading | positive regulation of cell morphogenesis involved in differentiation | acylglycerol metabolic process | regulation of inflammatory response | chemotaxis | lipid homeostasis | positive regulation of substrate adhesion-dependent cell spreading | regulation of cellular component organization | regulation of cytoskeleton organization | positive regulation of signaling | signal transduction | regulation of signaling | animal organ regeneration | post-translational protein modification | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | intracellular membrane-bounded organelle | extracellular matrix | cytoplasmic vesicle | cell | spherical high-density lipoprotein particle | cytoplasmic vesicle lumen | cytoplasm | endocytic vesicle lumen | collagen-containing extracellular matrix | intracellular organelle | lipoprotein particle | endoplasmic reticulum | protein-containing complex | secretory vesicle | endomembrane system | intermediate-density lipoprotein particle | plasma membrane | protein-lipid complex | discoidal high-density lipoprotein particle | vesicle | endoplasmic reticulum lumen | extracellular exosome | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | low-density lipoprotein particle | nucleus | organelle | very-low-density lipoprotein particle | high-density lipoprotein particle | extracellular space | cell periphery | membrane-enclosed lumen | early endosome | plasma lipoprotein particle | secretory granule lumen | blood microparticle | cytosol | intracellular vesicle | cell surface | endocytic vesicle | intracellular | membrane | vesicle lumen | chylomicron