QuickView for APOBEC3A (gene)

Gene Symbol:

APOBEC3A Homo sapiens

Full name:

apolipoprotein B mRNA editing enzyme catalytic subunit 3A

Synonyms:

A3A, ARP3, PHRBN, bK150C2.1, DNA dC->dU-editing enzyme APOBEC-3A, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A, phorbolin-1, probable DNA dC->dU-editing enzyme APOBEC-3A

Genomic Location:

Chr 22: 37683569-37689134

Description:

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by...

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This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Cytogenetic Map:

22q13.1

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