QuickView for APP;jsessionid=F4C76F25907D3E6539736709FFBA13C5 (gene)

Gene Symbol:

APP Homo sapiens

Full name:

amyloid beta precursor protein

Synonyms:

AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, preA4, amyloid-beta A4 protein, alzheimer disease amyloid protein, amyloid beta (A4) precursor protein, amyloid beta A4 protein, amyloid precursor protein, beta-amyloid peptide, beta-amyloid peptide(1-40), beta-amyloid peptide(1-42), beta-amyloid precursor protein, cerebral vascular amyloid peptide, peptidase nexin-II, protease nexin-II, testicular tissue protein Li 2

Genomic Location:

Chr 21: 26174732-26465003

Description:

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains ...

View Full Description

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FXR_Q3 ,  SMTTTTGT_UNKNOWN ,  TGANTCA_AP1_C ,  TCANNTGAY_SREBP1_01 ,  GGGATGC_MIR3245P ,  ATTACAT_MIR3803P ,  NGFIC_01 ,  AAANWWTGC_UNKNOWN ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  CTATGCA_MIR153 ,  YATTNATC_UNKNOWN ,  FXR_IR1_Q6 ,  GTACTGT_MIR101 ,  TGACCTY_ERR1_Q2 ,  CAGGTG_E12_Q6 ,  PXR_Q2 ,  RRAGTTGT_UNKNOWN ,  YGCANTGCR_UNKNOWN ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  PITX2_Q2 ,  TCTCTCC_MIR185 ,  AREB6_03 ,  RNGTGGGC_UNKNOWN ,  TTGTTT_FOXO4_01 ,  SREBP_Q3 ,  CTGCAGY_UNKNOWN ,  GTGGGTGK_UNKNOWN ,  AAGCACT_MIR520F ,  CTTTGT_LEF1_Q2 ,  EGR1_01 ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ERR1_Q2 ,  TCF1P_Q6 ,  TCGATGG_MIR213 ,  TGACCTTG_SF1_Q6

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-324-5p ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-383 ,  Predicted Gene Targets for miR-93

Cytogenetic Map:

21q21.3

search → result