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QuickView for AQP1 (gene)


Gene Symbol:
AQP1 Homo sapiens Homo sapiens
Full name:
aquaporin 1 (Colton blood group)
Synonyms:
AQP-CHIP, CHIP28, CO, aquaporin-1, aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group), aquaporin 1, Colton blood group antigen, aquaporin-CHIP, channel-like integral membrane protein, 28-kDa, urine water channel, water channel protein for red blood cells and kidney proximal tubule
Genomic Location:
Chr 7: 30917993-30931656
Description:
This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Bos taurus Danio rerio Canis lupus familiaris Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 7
7p14.3





GO Molecular Function

glycerol transmembrane transporter activity | intracellular cGMP-activated cation channel activity | ammonium transmembrane transporter activity | passive transmembrane transporter activity | neurotransmitter transporter activity | water transmembrane transporter activity | transmembrane transporter activity | ligand-gated ion channel activity | ion gated channel activity | polyol transmembrane transporter activity | cyclic nucleotide-gated ion channel activity | intracellular cyclic nucleotide activated cation channel activity | cation transmembrane transporter activity | transporter activity | identical protein binding | ion transmembrane transporter activity | drug transmembrane transporter activity | protein binding | potassium channel activity | water channel activity | metal ion transmembrane transporter activity | potassium ion transmembrane transporter activity | carbon dioxide transmembrane transporter activity | carbohydrate transmembrane transporter activity | cation channel activity | nitric oxide transmembrane transporter activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | intracellular ligand-gated ion channel activity | channel activity | ion channel activity | substrate-specific channel activity

GO Biological Process

brain development | response to radiation | cellular response to decreased oxygen levels | regulation of cysteine-type endopeptidase activity | actin filament-based process | hyperosmotic response | intracellular signal transduction | regulation of localization | regulation of programmed cell death | negative regulation of cysteine-type endopeptidase activity | actin cytoskeleton organization | establishment of localization | response to hormone | negative regulation of cellular process | positive regulation of developmental process | response to dexamethasone | response to metal ion | positive regulation of fibroblast proliferation | nervous system development | fluid transport | response to drug | renal water homeostasis | glycerol transmembrane transporter activity | polyol transport | response to antibiotic | intracellular cGMP-activated cation channel activity | negative regulation of proteolysis | interaction with symbiont | response to organophosphorus | cellular process | secretion | ammonium transmembrane transporter activity | localization | cellular homeostasis | odontogenesis | passive transmembrane transporter activity | metal ion transport | cellular response to nitric oxide | neurotransmitter transporter activity | anion transport | regulation of digestive system process | negative regulation of apoptotic process | response to hypoxia | regulation of proteolysis | water transmembrane transporter activity | transepithelial transport | response to inorganic substance | negative regulation of cellular metabolic process | interspecies interaction between organisms | cellular response to retinoic acid | response to hydrogen peroxide | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | transmembrane transporter activity | ligand-gated ion channel activity | cellular response to organonitrogen compound | cellular component organization | cellular response to metal ion | ventricular system development | response to UV | head development | regulation of vasculature development | response to stimulus | ion gated channel activity | cellular response to mechanical stimulus | positive regulation of saliva secretion | response to salt stress | cellular response to light stimulus | cellular response to xenobiotic stimulus | cellular response to hypoxia | response to stress | regulation of cell proliferation | carbon dioxide transport | multicellular organismal homeostasis | cellular response to inorganic substance | organic hydroxy compound transport | cellular response to toxic substance | polyol transmembrane transporter activity | cellular response to organic cyclic compound | negative regulation of metabolic process | regulation of cellular component size | water transport | water homeostasis | carbon dioxide transmembrane transport | establishment or maintenance of actin cytoskeleton polarity | response to nitrogen compound | cellular response to hormone stimulus | response to light stimulus | system development | response to oxygen levels | cyclic nucleotide-gated ion channel activity | cellular response to antibiotic | multicellular organism development | negative regulation of catalytic activity | intracellular cyclic nucleotide activated cation channel activity | regulation of peptidase activity | cGMP-mediated signaling | response to purine-containing compound | regulation of catalytic activity | cellular response to oxidative stress | pancreatic juice secretion | ion transmembrane transport | negative regulation of peptidase activity | telencephalon development | positive regulation of secretion | organic substance transport | response to ketone | cellular response to stress | response to lipid | cation transmembrane transporter activity | modification of morphology or physiology of other organism | digestive system process | cellular response to radiation | monovalent inorganic cation transport | animal organ morphogenesis | cellular response to oxygen levels | response to mercury ion | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | response to corticosteroid | cellular potassium ion transport | response to oxidative stress | positive regulation of digestive system process | ion transmembrane transporter activity | potassium ion transport | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | second-messenger-mediated signaling | response to osmotic stress | regulation of cellular protein metabolic process | cellular response to glucocorticoid stimulus | bicarbonate transport | organic anion transport | lateral ventricle development | response to toxic substance | response to xenobiotic stimulus | cellular response to corticosteroid stimulus | establishment or maintenance of cell polarity | cellular response to UV | cellular response to drug | cell communication | regulation of cellular metabolic process | cellular response to mercury ion | drug transmembrane transporter activity | cyclic-nucleotide-mediated signaling | regulation of protein metabolic process | homeostatic process | positive regulation of cell proliferation | positive regulation of transport | response to retinoic acid | carbohydrate transport | cellular hyperosmotic response | transepithelial water transport | carbohydrate transmembrane transport | cation transmembrane transport | potassium channel activity | regulation of fibroblast proliferation | water channel activity | response to organic substance | epithelial fluid transport | cellular response to reactive nitrogen species | response to antineoplastic agent | response to mechanical stimulus | metal ion transmembrane transporter activity | cellular response to osmotic stress | regulation of saliva secretion | anatomical structure development | potassium ion transmembrane transporter activity | regulation of body fluid levels | negative regulation of programmed cell death | carbon dioxide transmembrane transporter activity | cellular response to hydrogen peroxide | chemical homeostasis | regulation of secretion | body fluid secretion | ammonium transmembrane transport | cellular response to reactive oxygen species | response to copper ion | nitric oxide transport | animal organ development | response to reactive oxygen species | forebrain development | negative regulation of cellular protein metabolic process | cellular response to salt stress | carbohydrate transmembrane transporter activity | cellular response to cAMP | renal water transport | cytoskeleton organization | inorganic cation transmembrane transport | cellular response to steroid hormone stimulus | renal system process | cerebrospinal fluid secretion | response to cAMP | cellular response to dexamethasone stimulus | drug transport | cation channel activity | negative regulation of protein metabolic process | negative regulation of molecular function | nitric oxide transmembrane transporter activity | glycerol transport | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | response to organic cyclic compound | monovalent inorganic cation transmembrane transporter activity | intracellular ligand-gated ion channel activity | drug transmembrane transport | regulation of cell size | anatomical structure morphogenesis | regulation of endopeptidase activity | cation transport | channel activity | ammonium transport | regulation of developmental process | developmental process | organelle organization | digestion | regulation of transport | neurotransmitter transport | multicellular organismal water homeostasis | response to organonitrogen compound | potassium ion transmembrane transport | establishment or maintenance of cytoskeleton polarity | negative regulation of hydrolase activity | central nervous system development | ion channel activity | maintenance of symbiont-containing vacuole by host | ion transport | cellular response to organic substance | regulation of cell death | cellular response to copper ion | response to nitric oxide | response to steroid hormone | negative regulation of cell death | substrate-specific channel activity | positive regulation of angiogenesis | cell volume homeostasis | signal transduction | negative regulation of endopeptidase activity | response to glucocorticoid | multicellular organismal process

GO Cellular Component

brush border | integral component of membrane | basal plasma membrane | intracellular membrane-bounded organelle | sarcolemma | apical plasma membrane | host cell | organelle membrane | cell projection membrane | nuclear membrane | basal part of cell | cell | intrinsic component of membrane | other organism cell | cytoplasm | intracellular organelle | brush border membrane | apical part of cell | cell projection | endomembrane system | plasma membrane | nuclear envelope | vesicle | extracellular membrane-bounded organelle | symbiont-containing vacuole membrane | extracellular exosome | integral component of plasma membrane | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cell periphery | basolateral plasma membrane | symbiont-containing vacuole | intracellular | membrane | intrinsic component of plasma membrane