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QuickView for AR (gene)


Gene Symbol:
AR Homo sapiens Homo sapiens
Full name:
androgen receptor
Synonyms:
AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM, androgen receptor, dihydrotestosterone receptor, nuclear receptor subfamily 3 group C member 4
Genomic Location:
Chr X: 66680599-66860844
Description:
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, transloc...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Bos taurus Canis lupus familiaris Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr X
Xq12





GO Molecular Function

sequence-specific DNA binding | beta-catenin binding | transcription regulatory region DNA binding | androgen binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nuclear receptor activity | cation binding | transcription factor activity, direct ligand regulated sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | lipid binding | signaling receptor binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | steroid hormone receptor activity | chromatin binding | protein domain specific binding | ATPase binding | RNA polymerase II regulatory region DNA binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | androgen receptor activity | ion binding | organic cyclic compound binding | hormone binding | transcription regulatory region sequence-specific DNA binding | protein binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | protein dimerization activity | POU domain binding | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transition metal ion binding | steroid binding | metal ion binding | heterocyclic compound binding

GO Biological Process

protein modification by small protein removal | RNA metabolic process | transcription by RNA polymerase II | DNA-templated transcription, initiation | cell morphogenesis | positive regulation of macromolecule biosynthetic process | somatic sex determination | positive regulation of cellular component organization | male sex determination | developmental process involved in reproduction | regulation of cellular localization | proteolysis | regulation of integrin biosynthetic process | regulation of localization | mammary gland duct morphogenesis | prostate gland growth | regulation of epithelial cell proliferation involved in prostate gland development | morphogenesis of an epithelium | positive regulation of DNA-binding transcription factor activity | positive regulation of embryonic development | gonad development | regulation of programmed cell death | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | regulation of protein localization to membrane | cell differentiation | positive regulation of epithelial cell proliferation | male gamete generation | multicellular organism growth | androgen receptor signaling pathway | organ growth | positive regulation of phosphate metabolic process | tertiary branching involved in mammary gland duct morphogenesis | hormone-mediated signaling pathway | positive regulation of cellular biosynthetic process | cellular process | Leydig cell differentiation | nuclear receptor activity | epithelial tube morphogenesis | negative regulation of signaling | developmental growth | reproductive system development | regulation of embryonic development | female pregnancy | transcription factor activity, direct ligand regulated sequence-specific DNA binding | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | negative regulation of apoptotic process | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of transcription by RNA polymerase III | regulation of cell differentiation | gamete generation | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | male genitalia morphogenesis | cellular aromatic compound metabolic process | cellular component organization | protein deubiquitination | prostate gland epithelium morphogenesis | urogenital system development | mammary gland morphogenesis | development of primary sexual characteristics | response to stimulus | regulation of cellular protein localization | positive regulation of protein metabolic process | gland morphogenesis | regulation of intracellular steroid hormone receptor signaling pathway | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | tube morphogenesis | epithelial cell development | positive regulation of transcription by RNA polymerase III | reproduction | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | blood circulation | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | steroid hormone receptor activity | protein modification process | steroid hormone mediated signaling pathway | cellular biosynthetic process | embryo development | regulation of morphogenesis of a branching structure | macromolecule modification | cell-cell signaling | epithelial cell morphogenesis | regulation of nucleic acid-templated transcription | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | lateral sprouting involved in mammary gland duct morphogenesis | multicellular organism development | regulation of MAPK cascade | mammary gland development | epithelial cell differentiation involved in prostate gland development | protein complex oligomerization | regulation of catalytic activity | regulation of intracellular estrogen receptor signaling pathway | regulation of phosphorylation | seminiferous tubule development | mammary gland lobule development | regulation of gene expression | lateral sprouting from an epithelium | regulation of extrinsic apoptotic signaling pathway | regulation of cell fate specification | response to ketone | response to lipid | regulation of blood pressure | cellular response to testosterone stimulus | regulation of systemic arterial blood pressure | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | morphogenesis of an epithelial fold | positive regulation of cell differentiation | negative regulation of extrinsic apoptotic signaling pathway | cell proliferation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | fertilization | positive regulation of epithelial cell proliferation involved in prostate gland development | male somatic sex determination | sex determination | androgen receptor activity | regulation of apoptotic signaling pathway | cell morphogenesis involved in differentiation | positive regulation of intracellular estrogen receptor signaling pathway | chordate embryonic development | animal organ formation | cell communication | regulation of cellular metabolic process | response to testosterone | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | genitalia development | single fertilization | positive regulation of molecular function | multicellular organism reproduction | maternal process involved in female pregnancy | protein-containing complex assembly | development of primary male sexual characteristics | negative regulation of epithelial cell proliferation | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | DNA-binding transcription factor activity | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | tissue morphogenesis | regulation of prostatic bud formation | regulation of insulin-like growth factor receptor signaling pathway | branching morphogenesis of an epithelial tube | male sex differentiation | regulation of animal organ morphogenesis | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | metabolic process | regulation of protein localization to plasma membrane | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | male gonad development | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | male genitalia development | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | mammary gland branching involved in pregnancy | positive regulation of NF-kappaB transcription factor activity | protein modification by small protein conjugation or removal | genitalia morphogenesis | regulation of phosphate metabolic process | mammary gland epithelium development | cellular response to steroid hormone stimulus | prostate gland morphogenesis | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | positive regulation of MAPK cascade | intracellular receptor signaling pathway | morphogenesis of a branching epithelium | mammary gland alveolus development | anatomical structure formation involved in morphogenesis | regulation of animal organ formation | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | positive regulation of intracellular steroid hormone receptor signaling pathway | cell development | regulation of developmental growth | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | morphogenesis of a branching structure | anatomical structure morphogenesis | prostate gland development | cellular macromolecule biosynthetic process | reproductive structure development | regulation of developmental process | activation of prostate induction by androgen receptor signaling pathway | developmental process | spermatogenesis | intracellular steroid hormone receptor signaling pathway | cellular protein modification process | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of cell fate commitment | in utero embryonic development | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | sex differentiation | response to steroid hormone | negative regulation of cell death | positive regulation of insulin-like growth factor receptor signaling pathway | branching involved in mammary gland duct morphogenesis | sexual reproduction | regulation of cellular component organization | positive regulation of integrin biosynthetic process | positive regulation of signaling | negative regulation of integrin biosynthetic process | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | protein-containing complex | nucleoplasm | plasma membrane | chromatin | nuclear chromosome | nuclear speck | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | nuclear chromatin | cytosol | intracellular | membrane