Correlation Engine 2.0
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QuickView for ARSA (gene)

Gene Symbol:
ARSA Homo sapiens Homo sapiens
Full name:
arylsulfatase A
MLD, arylsulfatase A, ASA, cerebroside-sulfatase
Genomic Location:
Chr 22: 49410315-49413473
The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 22

GO Molecular Function

cation binding | hydrolase activity | catalytic activity | cerebroside-sulfatase activity | hydrolase activity, acting on ester bonds | arylsulfatase activity | ion binding | protein binding | calcium ion binding | sulfuric ester hydrolase activity | metal ion binding

GO Biological Process

exocytosis | neutrophil activation | glycosphingolipid metabolic process | establishment of localization | cellular process | secretion | leukocyte degranulation | localization | sphingolipid metabolic process | leukocyte activation | cellular lipid metabolic process | response to stimulus | neutrophil degranulation | leukocyte activation involved in immune response | secretion by cell | nitrogen compound metabolic process | leukocyte mediated immunity | lipid metabolic process | vesicle-mediated transport | glycolipid metabolic process | regulated exocytosis | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | metabolic process | membrane lipid metabolic process | immune response | organic substance metabolic process | cell activation | carbohydrate derivative metabolic process | neutrophil mediated immunity | immune system process | cellular metabolic process

GO Cellular Component

secretory granule | azurophil granule lumen | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | vacuolar lumen | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | endoplasmic reticulum | secretory vesicle | endomembrane system | vacuole | vesicle | endoplasmic reticulum lumen | extracellular exosome | lytic vacuole | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | lysosome | extracellular space | membrane-enclosed lumen | azurophil granule | lysosomal lumen | secretory granule lumen | intracellular vesicle | intracellular | vesicle lumen