QuickView for ASCC1 (gene)

Gene Symbol:

ASCC1 Homo sapiens

Full name:

activating signal cointegrator 1 complex subunit 1

Synonyms:

ASC1p50, CGI-18, SMABF2, p50, activating signal cointegrator 1 complex subunit 1, ASC-1 complex subunit P50, trip4 complex subunit p50

Genomic Location:

Chr 10: 73526284-73645700

Description:

This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein cont...

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This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGTYNNNNNRGCARM_UNKNOWN ,  ERR1_Q2

Cytogenetic Map:

10q22.1

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