QuickView for ATM (gene)
- Gene Symbol:
- ATM
Homo sapiens - Full name:
- ATM serine/threonine kinase
- Synonyms:
- AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, serine-protein kinase ATM, A-T mutated, AT mutated, TEL1, telomere maintenance 1, homolog, ataxia telangiectasia mutated
- Genomic Location:
- Chr 11: 107598769-107745036
- Description:
-
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repai...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Schizosaccharomyces pombe , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
11q22.3
GO Molecular Function
nucleic acid binding | protein-containing complex binding | ribonucleotide binding | DNA-dependent protein kinase activity | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | protein N-terminus binding | anion binding | adenyl nucleotide binding | DNA binding | purine nucleotide binding | phosphatidylinositol 3-kinase activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | 1-phosphatidylinositol-3-kinase activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
RNA metabolic process | negative regulation of leukocyte activation | negative regulation of TOR signaling | regulation of telomere maintenance via telomerase | double-strand break repair | response to radiation | cellular response to X-ray | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | telomere maintenance | negative regulation of immune system process | positive regulation of cellular component organization | regulation of B cell activation | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell cycle G1/S phase transition | regulation of programmed cell death | peptidyl-amino acid modification | response to X-ray | phosphatidylinositol metabolic process | establishment of localization | regulation of autophagy | regulation of immune system process | negative regulation of cellular process | signal transduction involved in mitotic G2 DNA damage checkpoint | histone modification | cell differentiation | intrinsic apoptotic signaling pathway in response to DNA damage | negative regulation of B cell proliferation | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | positive regulation of phosphate metabolic process | regulation of organelle organization | phosphatidylinositol-3-phosphate biosynthetic process | B cell differentiation | phospholipid metabolic process | negative regulation of DNA metabolic process | regulation of neuron death | regulation of chromosome segregation | positive regulation of cellular biosynthetic process | cellular process | positive regulation of signal transduction by p53 class mediator | organic substance catabolic process | histone mRNA catabolic process | lymphocyte differentiation | localization | chromatin organization | mitotic DNA integrity checkpoint | regulation of DNA damage response, signal transduction by p53 class mediator | negative regulation of signaling | negative regulation of G1/S transition of mitotic cell cycle | regulation of mitotic nuclear division | immune system development | regulation of chromosome separation | macromolecule localization | regulation of histone modification | negative regulation of chromosome segregation | response to hypoxia | regulation of cell cycle | regulation of cellular response to gamma radiation | positive regulation of nitrogen compound metabolic process | cellular response to nitrosative stress | negative regulation of cellular metabolic process | negative regulation of mitotic metaphase/anaphase transition | anatomical structure homeostasis | intrinsic apoptotic signaling pathway | DNA damage induced protein phosphorylation | spindle checkpoint | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | catabolic process | regulation of protein complex assembly | negative regulation of mononuclear cell proliferation | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | regulation of G2/M transition of mitotic cell cycle | pre-B cell differentiation | cellular component organization | positive regulation of response to DNA damage stimulus | cellular lipid metabolic process | DNA-dependent protein kinase activity | mRNA catabolic process | regulation of telomere capping | response to stimulus | regulation of mitotic cell cycle phase transition | regulation of cellular response to heat | histone mRNA metabolic process | positive regulation of protein metabolic process | response to stress | negative regulation of G2/M transition of mitotic cell cycle | negative regulation of lymphocyte activation | regulation of cell proliferation | mitotic G2 DNA damage checkpoint | regulation of cell cycle phase transition | protein serine/threonine kinase activity | programmed cell death | reproduction | cellular localization | positive regulation of telomerase catalytic core complex assembly | cellular nitrogen compound metabolic process | telomere organization | double-strand break repair via nonhomologous end joining | negative regulation of metabolic process | hemopoiesis | protein modification process | mRNA metabolic process | nuclear-transcribed mRNA catabolic process | cellular biosynthetic process | establishment of protein-containing complex localization to telomere | DNA recombination | macromolecule modification | nucleobase-containing compound catabolic process | regulation of TOR signaling | positive regulation of telomere maintenance via telomere lengthening | DNA repair | leukocyte differentiation | regulation of cellular response to stress | apoptotic process | positive regulation of DNA catabolic process | regulation of cell cycle G2/M phase transition | regulation of histone phosphorylation | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | DNA damage response, signal transduction by p53 class mediator | mitotic DNA damage checkpoint | multicellular organism development | negative regulation of cell cycle G2/M phase transition | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of telomere maintenance | regulation of catalytic activity | lipid metabolic process | regulation of phosphorylation | positive regulation of DNA damage response, signal transduction by p53 class mediator | response to nitrosative stress | positive regulation of chromosome organization | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | regulation of TORC1 signaling | cellular response to stress | DNA double-strand break processing | cell cycle | RNA catabolic process | organophosphate metabolic process | regulation of signal transduction by p53 class mediator | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of telomerase activity | regulation of lymphocyte activation | cellular response to radiation | phospholipid biosynthetic process | protein autophosphorylation | regulation of mitotic sister chromatid separation | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | phosphatidylinositol 3-kinase activity | cellular response to gamma radiation | negative regulation of mitotic nuclear division | B cell activation | biosynthetic process | regulation of cellular protein metabolic process | phosphorylation | lipid biosynthetic process | positive regulation of neuron death | establishment of RNA localization | positive regulation of telomere maintenance via telomerase | signal transduction involved in cell cycle checkpoint | mitotic spindle assembly checkpoint | protein phosphorylation | response to gamma radiation | immature B cell differentiation | phosphate-containing compound metabolic process | regulation of macrophage activation | lipid phosphorylation | regulation of telomere maintenance via telomere lengthening | mitotic G1 DNA damage checkpoint | cell communication | regulation of cellular metabolic process | negative regulation of mitotic sister chromatid segregation | regulation of neuron apoptotic process | positive regulation of DNA biosynthetic process | negative regulation of cell activation | protein-containing complex localization | regulation of protein metabolic process | positive regulation of signal transduction | aromatic compound catabolic process | lipid modification | homeostatic process | negative regulation of mitotic sister chromatid separation | regulation of protein phosphorylation | glycerolipid metabolic process | histone phosphorylation | negative regulation of telomere maintenance | apoptotic signaling pathway | cell aging | negative regulation of B cell activation | regulation of mitotic cell cycle | lymphocyte activation | pre-B cell allelic exclusion | positive regulation of cell cycle arrest | mitotic G2/M transition checkpoint | protein metabolic process | positive regulation of protein modification process | G1 DNA damage checkpoint | glycerophospholipid biosynthetic process | 1-phosphatidylinositol-3-kinase activity | cell cycle arrest | DNA metabolic process | replicative senescence | reciprocal meiotic recombination | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | regulation of sister chromatid segregation | positive regulation of neuron apoptotic process | peptidyl-serine autophosphorylation | anatomical structure development | mitotic cell cycle | nuclear division | metabolic process | negative regulation of leukocyte proliferation | negative regulation of mitotic cell cycle | positive regulation of cell death | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | signal transduction involved in G2 DNA damage checkpoint | protein kinase activity | positive regulation of cellular component biogenesis | organic substance metabolic process | cell death | negative regulation of gene expression | animal organ development | positive regulation of histone modification | regulation of cell activation | positive regulation of programmed cell death | signal transduction involved in mitotic cell cycle checkpoint | cellular response to ionizing radiation | regulation of phosphate metabolic process | regulation of chromosome organization | phosphatidylinositol biosynthetic process | negative regulation of TORC1 signaling | meiosis I | cell activation | negative regulation of cell cycle | regulation of mitotic sister chromatid segregation | meiotic cell cycle | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | negative regulation of chromosome organization | negative regulation of signal transduction | signaling | covalent chromatin modification | positive regulation of phosphorylation | cellular protein metabolic process | phosphatidylinositol phosphorylation | cellular macromolecule localization | cellular macromolecule biosynthetic process | homologous recombination | signal transduction involved in DNA damage checkpoint | glycerophospholipid metabolic process | positive regulation of telomere maintenance | positive regulation of DNA metabolic process | kinase activity | negative regulation of telomere capping | developmental process | organelle organization | regulation of DNA biosynthetic process | positive regulation of cell cycle process | peptidyl-serine phosphorylation | cellular protein modification process | mitotic G1/S transition checkpoint | regulation of B cell proliferation | negative regulation of cell proliferation | regulation of mitotic metaphase/anaphase transition | heterocycle metabolic process | signal transduction involved in mitotic G1 DNA damage checkpoint | positive regulation of metabolic process | chromosome organization | negative regulation of lymphocyte proliferation | regulation of microglial cell activation | immune system process | mitotic cell cycle checkpoint | cellular metabolic process | hematopoietic or lymphoid organ development | negative regulation of cell cycle process | regulation of cell death | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | DNA replication | positive regulation of histone phosphorylation | aging | RNA localization | regulation of cellular component organization | response to ionizing radiation | establishment of RNA localization to telomere | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization | regulation of phosphorus metabolic process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | cytoplasmic vesicle | DNA repair complex | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | nuclear chromosome | vesicle | chromosome, telomeric region | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular vesicle | nuclear chromosome, telomeric region | intracellular
