QuickView for ATOX1 (gene)

Gene Symbol:

ATOX1 Homo sapiens

Full name:

antioxidant 1 copper chaperone

Synonyms:

ATX1, HAH1, copper transport protein ATOX1, ATX1 antioxidant protein 1 homolog, metal transport protein ATX1

Genomic Location:

Chr 5: 151102576-151118403

Description:

This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in ca...

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This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus ,  Pan troglodytes ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CAGGTG_E12_Q6

Cytogenetic Map:

5q33.1

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