QuickView for ATP1A2;jsessionid=92271347B9F0B06840E10B1EA524794E (gene)

Gene Symbol:

ATP1A2 Homo sapiens

Full name:

ATPase Na+/K+ transporting subunit alpha 2

Synonyms:

FHM2, MHP2, sodium/potassium-transporting ATPase subunit alpha-2, ATPase Na+/K+ transporting alpha 2 polypeptide, Na(+)/K(+) ATPase alpha-2 subunit, Na+/K+ ATPase, alpha-A(+) catalytic polypeptide, Na+/K+ ATPase, alpha-B polypeptide, sodium pump subunit alpha-2, sodium-potassium ATPase catalytic subunit alpha-2, sodium/potassium-transporting ATPase alpha-2 chain

Genomic Location:

Chr 1: 158352172-158380005

Description:

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, f...

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The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  VDR_Q3 ,  SRF_Q6 ,  WGTTNNNNNAAA_UNKNOWN ,  TACTTGA_MIR26A_MIR26B ,  GGGAGGRR_MAZ_Q6 ,  MEF2_02 ,  TFIII_Q6 ,  CAGNYGKNAAA_UNKNOWN ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  CTTTAAR_UNKNOWN ,  AAAYRNCTG_UNKNOWN ,  MEF2_03 ,  T3R_Q6 ,  YWATTWNNRGCT_UNKNOWN ,  CAGCTG_AP4_Q5 ,  MZF1_02 ,  DR4_Q2 ,  OLF1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-26

Cytogenetic Map:

1q23.2

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