QuickView for ATP2B3;jsessionid=88BFBC24181686B5F95C308A74B592B1 (gene)

Gene Symbol:

ATP2B3 Homo sapiens

Full name:

ATPase plasma membrane Ca2+ transporting 3

Synonyms:

CFAP39, CLA2, OPCA, PMCA3, PMCA3a, SCAX1, plasma membrane calcium-transporting ATPase 3, ATPase, Ca++ transporting, plasma membrane 3, cilia and flagella associated protein 39, plasma membrane calcium ATPase, plasma membrane calcium pump

Genomic Location:

Chr X: 152454774-152501581

Description:

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium h...

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The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF1_01 ,  AAGCCAT_MIR135A_MIR135B ,  ATGTCAC_MIR489 ,  HEN1_01 ,  HP1SITEFACTOR_Q6 ,  VDR_Q6 ,  LYF1_01 ,  MEIS1BHOXA9_01 ,  HNF1_C ,  CAGGTG_E12_Q6 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  AGTCAGC_MIR345 ,  YKACATTT_UNKNOWN ,  CCCNNGGGAR_OLF1_01 ,  GATA4_Q3 ,  GTGGGTGK_UNKNOWN ,  CAGCTG_AP4_Q5 ,  TGACATY_UNKNOWN ,  TCF1P_Q6 ,  LMO2COM_01 ,  OLF1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-375

Cytogenetic Map:

Xq28

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