QuickView for ATP6V1A (gene)

Gene Symbol:

ATP6V1A Homo sapiens

Full name:

ATPase H+ transporting V1 subunit A

Synonyms:

ARCL2D, ATP6A1, ATP6V1A1, HO68, VA68, VPP2, Vma1, V-type proton ATPase catalytic subunit A, ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A, ATPase, H+ transporting, lysosomal, subunit A1, H(+)-transporting two-sector ATPase, subunit A, H+-transporting ATPase chain A, vacuolar (VA68 type), V-ATPase 69 kDa subunit 1, V-ATPase A subunit 1, V-ATPase subunit A, vacuolar ATP synthase catalytic subunit A, ubiquitous isoform, vacuolar ATPase isoform VA68, vacuolar proton pump alpha subunit 1, vacuolar proton pump subunit alpha

Genomic Location:

Chr 3: 114948598-115013593

Description:

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient ge...

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This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  ATGCAGT_MIR217 ,  AGCYRWTTC_UNKNOWN ,  TGANTCA_AP1_C ,  TCANNTGAY_SREBP1_01 ,  ARNT_01 ,  YTATTTTNR_MEF2_02 ,  CACGTG_MYC_Q2 ,  MAX_01 ,  CAGTGTT_MIR141_MIR200A ,  ARNT_02 ,  SREBP1_Q6 ,  TGACCTY_ERR1_Q2 ,  ACTGTGA_MIR27A_MIR27B ,  RGAANNTTC_HSF1_01 ,  AP1_Q6_01 ,  SREBP1_01 ,  ACATTCC_MIR1_MIR206 ,  GTGACGY_E4F1_Q6 ,  HSF1_01 ,  CAGCTTT_MIR320 ,  AP1FJ_Q2 ,  ATGTTAA_MIR302C ,  MGGAAGTG_GABP_B ,  TAATAAT_MIR126 ,  HSF_Q6 ,  NF1_Q6_01 ,  SOX5_01 ,  USF_01 ,  HSF2_01 ,  RORA1_01 ,  TTGTTT_FOXO4_01 ,  GTGGTGA_MIR197 ,  CAGCTG_AP4_Q5 ,  TGACATY_UNKNOWN ,  ERR1_Q2 ,  ER_Q6 ,  USF_02 ,  TCATCTC_MIR143 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-539

Cytogenetic Map:

3q13.31

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