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QuickView for ATP7A (gene)


Gene Symbol:
ATP7A Homo sapiens Homo sapiens
Full name:
ATPase copper transporting alpha
Synonyms:
DSMAX, MK, MNK, SMAX3, copper-transporting ATPase 1, ATPase, Cu++ transporting, alpha polypeptide, Cu++-transporting P-type ATPase, Menkes disease-associated protein, copper pump 1
Genomic Location:
Chr X: 77052876-77192208
Description:
This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in th...
Orthologs:
Mus musculus Rattus norvegicus C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Canis lupus familiaris Gallus gallus Pan troglodytes Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr X
Xq21.1





GO Molecular Function

transition metal ion transmembrane transporter activity | enzyme activator activity | ATPase activity, coupled to transmembrane movement of substances | GTPase binding | Rho GTPase binding | copper-dependent protein binding | cation binding | copper-exporting ATPase activity | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | enzyme binding | ribonucleotide binding | transmembrane transporter activity | superoxide dismutase copper chaperone activity | nucleotide binding | hydrolase activity | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | Ras GTPase binding | molecular function regulator | catalytic activity | chaperone binding | copper-transporting ATPase activity | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | cation transmembrane transporter activity | ATPase activity, coupled | cation-transporting ATPase activity | active transmembrane transporter activity | purine nucleotide binding | transporter activity | copper chaperone activity | ion transmembrane transporter activity | ion binding | organic cyclic compound binding | cuprous ion binding | copper ion binding | purine ribonucleoside triphosphate binding | protein binding | metal ion transmembrane transporter activity | Rac GTPase binding | hydrolase activity, acting on acid anhydrides | metallochaperone activity | transition metal ion binding | small GTPase binding | ATPase coupled ion transmembrane transporter activity | inorganic cation transmembrane transporter activity | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | drug binding | copper ion transmembrane transporter activity | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding

GO Biological Process

ATP hydrolysis coupled cation transmembrane transport | brain development | molting cycle | transition metal ion transmembrane transporter activity | cell morphogenesis | cellular response to decreased oxygen levels | positive regulation of locomotion | CD4-positive, alpha-beta T cell differentiation | epidermis morphogenesis | extracellular structure organization | positive regulation of cellular component organization | CD4-positive, alpha-beta T cell activation | neuron projection morphogenesis | enzyme activator activity | cellular response to platelet-derived growth factor stimulus | regulation of localization | catechol-containing compound metabolic process | morphogenesis of an epithelium | peptidyl-amino acid modification | superoxide metabolic process | ATPase activity, coupled to transmembrane movement of substances | establishment of localization | response to metal ion | cell differentiation | positive regulation of epithelial cell proliferation | respiratory tube development | nervous system development | reactive oxygen species metabolic process | cerebellum morphogenesis | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | cellular response to iron ion | elastin metabolic process | positive regulation of cellular component movement | generation of neurons | response to antibiotic | phenol-containing compound metabolic process | cellular process | secretion | lymphocyte differentiation | regulation of cell motility | localization | cellular homeostasis | cell projection morphogenesis | aromatic amino acid family metabolic process | cellular detoxification | tissue remodeling | copper-exporting ATPase activity | metal ion transport | neuron development | negative regulation of iron ion transmembrane transport | central nervous system neuron differentiation | immune system development | transition metal ion transport | response to hypoxia | positive regulation of oxidoreductase activity | response to growth factor | positive regulation of catalytic activity | forebrain neuron differentiation | copper ion homeostasis | response to inorganic substance | elastin biosynthetic process | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | tissue development | regulation of oxidative phosphorylation | epinephrine metabolic process | cellular amino acid metabolic process | cellular biogenic amine metabolic process | glycoprotein biosynthetic process | positive regulation of lamellipodium assembly | regulation of cellular process | positive regulation of lamellipodium organization | leukocyte activation | regulation of metabolic process | hepaticobiliary system development | T cell differentiation involved in immune response | transmembrane transporter activity | organic cyclic compound metabolic process | cellular response to cobalt ion | superoxide dismutase copper chaperone activity | epithelium development | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | cellular response to metal ion | T cell activation | head development | response to stimulus | serotonin metabolic process | vasculature development | respiratory system development | alpha-beta T cell activation involved in immune response | ATP hydrolysis coupled transmembrane transport | blood vessel remodeling | metencephalon development | cellular response to hypoxia | response to stress | leukocyte activation involved in immune response | regulation of cell proliferation | regulation of smooth muscle cell migration | supramolecular fiber organization | cellular response to inorganic substance | cell differentiation in hindbrain | cardiovascular system development | cellular response to cadmium ion | cellular nitrogen compound metabolic process | cellular response to toxic substance | extracellular matrix organization | negative regulation of transport | stress response to copper ion | carbohydrate derivative biosynthetic process | regulation of cellular component size | hemopoiesis | cellular component assembly | protein modification process | cartilage development | amine metabolic process | cellular biosynthetic process | embryo development | mitochondrion organization | response to iron ion | macromolecule modification | dopamine metabolic process | negative regulation of transmembrane transport | molecular function regulator | pyramidal neuron development | metal ion homeostasis | blood vessel development | cerebellar Purkinje cell layer formation | positive regulation of vascular associated smooth muscle cell migration | T-helper cell differentiation | leukocyte differentiation | regulation of neurotransmitter levels | organic hydroxy compound metabolic process | response to nitrogen compound | central nervous system neuron development | lung alveolus development | copper-transporting ATPase activity | regulation of cell projection assembly | regulation of proton transport | system development | response to oxygen levels | removal of superoxide radicals | positive regulation of response to wounding | nitrogen compound metabolic process | cellular response to antibiotic | multicellular organism development | negative regulation of catalytic activity | response to amino acid | mammary gland development | positive regulation of smooth muscle cell migration | plasma membrane copper ion transport | regulation of catalytic activity | cerebellum development | cellular response to oxidative stress | forebrain neuron development | regulation of phosphorylation | ATP hydrolysis coupled ion transmembrane transport | ion transmembrane transport | hair follicle morphogenesis | elastic fiber assembly | regulation of gene expression | cellular response to stress | stress response to metal ion | cation transmembrane transporter activity | cellular ion homeostasis | cation-transporting ATPase activity | response to manganese ion | liver development | cellular response to oxygen levels | response to superoxide | regulation of nitrogen compound metabolic process | regulation of cell migration | active transmembrane transporter activity | small molecule metabolic process | positive regulation of cell projection organization | cellular response to lead ion | regulation of cellular component movement | alpha-beta T cell differentiation | response to oxidative stress | response to oxygen radical | pigmentation | ion transmembrane transporter activity | cerebellar Purkinje cell differentiation | response to platelet-derived growth factor | neurotransmitter metabolic process | positive regulation of cell migration | negative regulation of ion transmembrane transport | biosynthetic process | response to cadmium ion | locomotory behavior | cellular copper ion homeostasis | copper ion transmembrane transport | hindbrain development | T cell activation involved in immune response | negative regulation of ion transport | norepinephrine metabolic process | epidermis development | response to toxic substance | skin development | cellular response to amino acid stimulus | cation homeostasis | chordate embryonic development | cellular cation homeostasis | regulation of cellular metabolic process | cell activation involved in immune response | cerebellar cortex morphogenesis | detoxification of copper ion | pyramidal neuron differentiation | homeostatic process | positive regulation of cell proliferation | response to zinc ion | regulation of locomotion | embryo development ending in birth or egg hatching | drug metabolic process | carboxylic acid metabolic process | lymphocyte activation | positive regulation of molecular function | neuron differentiation | cation transmembrane transport | T cell differentiation | protein metabolic process | hair cycle | response to organic substance | gland development | tissue morphogenesis | catecholamine metabolic process | lactation | metal ion transmembrane transporter activity | anatomical structure development | negative regulation of iron ion transport | cell projection organization | copper ion import | metabolic process | cellular oxidant detoxification | regulation of body fluid levels | cerebellar cortex development | peptidyl-lysine modification | hindbrain morphogenesis | hair cycle process | chemical homeostasis | forebrain generation of neurons | behavior | body fluid secretion | immune response | cellular response to reactive oxygen species | neuron projection development | positive regulation of cellular component biogenesis | organic substance metabolic process | response to copper ion | connective tissue development | copper ion export | cerebellar Purkinje cell layer development | animal organ development | response to reactive oxygen species | forebrain development | copper ion transport | alpha-beta T cell activation | ion homeostasis | skin epidermis development | regulation of ATP metabolic process | regulation of phosphate metabolic process | inorganic cation transmembrane transport | regulation of ion transmembrane transport | response to iron(III) ion | cell activation | lung development | anatomical structure formation involved in morphogenesis | cerebellar cortex formation | regulation of response to wounding | ATPase coupled ion transmembrane transporter activity | negative regulation of molecular function | transmembrane transport | inorganic cation transmembrane transporter activity | regulation of oxidoreductase activity | cell development | regulation of transmembrane transporter activity | collagen fibril organization | regulation of epithelial cell proliferation | organic acid metabolic process | regulation of ion transmembrane transporter activity | cellular protein metabolic process | regulation of cell size | enzyme regulator activity | anatomical structure morphogenesis | cation transport | cellular macromolecule biosynthetic process | positive regulation of plasma membrane bounded cell projection assembly | extracellular matrix assembly | regulation of ion transport | developmental process | organelle organization | positive regulation of cell size | cellular protein modification process | copper ion transmembrane transporter activity | tube development | carbohydrate derivative metabolic process | regulation of transport | detoxification | regulation of lamellipodium assembly | response to organonitrogen compound | cellular metal ion homeostasis | response to cobalt ion | heterocycle metabolic process | response to lead ion | tryptophan metabolic process | cellular response to superoxide | central nervous system development | regulation of generation of precursor metabolites and energy | in utero embryonic development | positive regulation of metabolic process | ion transport | cerebellar Purkinje cell layer morphogenesis | regulation of cell projection organization | transition metal ion homeostasis | skeletal system development | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | cellular response to copper ion | positive regulation of cell motility | circulatory system development | glycoprotein metabolic process | regulation of cellular component organization | hair follicle development | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of cytochrome-c oxidase activity | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | brush border | integral component of membrane | intracellular membrane-bounded organelle | late endosome | apical plasma membrane | neuron projection | endocytic vesicle membrane | somatodendritic compartment | organelle membrane | cell projection membrane | clathrin-coated vesicle | cytoplasmic vesicle | cell body | actin-based cell projection | cell | neuronal cell body | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | membrane microdomain | brush border membrane | apical part of cell | Golgi apparatus | cell projection | secretory vesicle | phagocytic vesicle membrane | endomembrane system | plasma membrane | perikaryon | Golgi-associated vesicle | cell leading edge | membrane raft | vesicle | transport vesicle | perinuclear region of cytoplasm | endosome | microvillus | membrane-bounded organelle | nucleus | organelle | vesicle membrane | cell periphery | basolateral plasma membrane | trans-Golgi network | trans-Golgi network transport vesicle | cytosol | intracellular vesicle | endocytic vesicle | intracellular | membrane | cytoplasmic vesicle membrane | phagocytic vesicle | coated vesicle