QuickView for AUF1 (gene)

Gene Symbol:

HNRNPD Homo sapiens

Full name:

heterogeneous nuclear ribonucleoprotein D

Synonyms:

AUF1, AUF1A, HNRPD, P37, hnRNPD0, heterogeneous nuclear ribonucleoprotein D0, ARE-binding protein AUFI, type A, AU-rich element RNA binding protein 1, 37kDa, hnRNP D0

Genomic Location:

Chr 4: 83493491-83514173

Description:

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabo...

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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  NFMUE1_Q6 ,  STAT4_01 ,  TGANTCA_AP1_C ,  AGTTCTC_MIR146A_MIR146B ,  USF_Q6 ,  ZIC1_01 ,  E2F1_Q4_01 ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  E2F4DP1_01 ,  CIZ_01 ,  E2F_Q6_01 ,  E2F_01 ,  GGTGAAG_MIR412 ,  MYCMAX_B ,  E2F1_Q4 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  GGGYGTGNY_UNKNOWN ,  E2F_Q6 ,  GGATTA_PITX2_Q2 ,  E2F1_Q6_01 ,  CAGNYGKNAAA_UNKNOWN ,  AR_01 ,  E2F_Q4 ,  GGGCGGR_SP1_Q6 ,  PITX2_Q2 ,  E2F1DP2_01 ,  E2F1_Q3_01 ,  CTTTAAR_UNKNOWN ,  USF_01 ,  E2F_03 ,  YCATTAA_UNKNOWN ,  E2F1DP1_01 ,  WCTCNATGGY_UNKNOWN ,  E2F_Q4_01 ,  CETS1P54_01 ,  USF_Q6_01 ,  YGCGYRCGC_UNKNOWN ,  E2F1DP1RB_01 ,  SCGGAAGY_ELK1_02 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  E2F_02 ,  GTGGTGA_MIR197 ,  NRF2_01 ,  E2F1_Q3 ,  ICSBP_Q6 ,  E2F4DP2_01 ,  PAX3_B ,  ZF5_B ,  E2F_Q3 ,  TGACATY_UNKNOWN ,  USF_02 ,  E2F_Q3_01 ,  E2F1_Q6 ,  SGCGSSAAA_E2F1DP2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-146 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-382

Cytogenetic Map:

4q21.22

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