QuickView for AURKA;jsessionid=22F855C2BFDD7F9C4867264A606F1DEF (gene)
- Gene Symbol:
- AURKA
Homo sapiens - Full name:
- aurora kinase A
- Synonyms:
- AIK, ARK1, AURA, BTAK, PPP1R47, STK15, STK6, STK7, aurora kinase A, aurora 2, aurora/IPL1-like kinase, aurora/IPL1-related kinase 1, breast tumor-amplified kinase, protein phosphatase 1, regulatory subunit 47, serine/threonine protein kinase 15, serine/threonine-protein kinase 6, serine/threonine-protein kinase aurora-A
- Genomic Location:
- Chr 20: 54377852-54400758
- Description:
-
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and prog...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
20q13.2
GO Molecular Function
kinase binding | protein kinase binding | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | ubiquitin-like protein ligase binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | protein heterodimerization activity | histone serine kinase activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | histone kinase activity | ubiquitin protein ligase binding | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | protein serine/threonine/tyrosine kinase activity | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
cell morphogenesis | regulation of cell cycle process | microtubule cytoskeleton organization involved in mitosis | positive regulation of cellular component organization | neuron projection morphogenesis | intracellular signal transduction | proteolysis | regulation of cell development | regulation of cell cycle G1/S phase transition | regulation of programmed cell death | regulation of oogenesis | peptidyl-amino acid modification | protein localization to centrosome | negative regulation of cellular process | positive regulation of developmental process | histone modification | microtubule cytoskeleton organization | cell differentiation | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | nervous system development | positive regulation of protein catabolic process | cell part morphogenesis | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | neurogenesis | regulation of organelle organization | generation of neurons | microtubule-based process | pattern specification process | regulation of oocyte development | neuron projection extension | cellular process | organic substance catabolic process | centrosome separation | localization | cell projection morphogenesis | proteolysis involved in cellular protein catabolic process | chromatin organization | mitotic DNA integrity checkpoint | developmental growth | neuron development | negative regulation of G1/S transition of mitotic cell cycle | regulation of mitotic nuclear division | multicellular organismal reproductive process | macromolecule localization | negative regulation of apoptotic process | microtubule organizing center organization | regulation of proteolysis | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | spindle assembly | regulation of binding | regulation of cell differentiation | gamete generation | regeneration | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | organelle localization | hepaticobiliary system development | female meiosis I | regulation of cell maturation | positive regulation of cellular protein metabolic process | signal transduction involved in mitotic DNA damage checkpoint | regulation of G2/M transition of mitotic cell cycle | cellular component organization | positive regulation of oogenesis | regulation of cell division | positive regulation of cellular protein catabolic process | response to stimulus | female gamete generation | regulation of mitotic cell cycle phase transition | regulation of centrosome cycle | positive regulation of protein metabolic process | mitotic spindle organization | regulation of cellular protein catabolic process | response to stress | negative regulation of G2/M transition of mitotic cell cycle | anaphase-promoting complex-dependent catabolic process | regulation of cell cycle phase transition | protein serine/threonine kinase activity | positive regulation of proteolysis involved in cellular protein catabolic process | reproduction | cellular protein catabolic process | cellular localization | positive regulation of proteolysis | proteasomal protein catabolic process | cellular component assembly | protein modification process | macromolecule modification | anterior/posterior pattern specification | organelle assembly | regulation of cell cycle G2/M phase transition | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | DNA damage response, signal transduction by p53 class mediator | regulation of protein stability | mitotic DNA damage checkpoint | multicellular organism development | negative regulation of cell cycle G2/M phase transition | phosphorus metabolic process | cellular response to DNA damage stimulus | positive regulation of cell cycle | positive regulation of mitotic cell cycle | signal transduction in response to DNA damage | cellular response to stress | cell cycle | protein catabolic process | spindle assembly involved in female meiosis | regulation of signal transduction by p53 class mediator | regulation of cell cycle arrest | positive regulation of cellular metabolic process | liver development | protein autophosphorylation | regulation of nitrogen compound metabolic process | protein localization to organelle | negative regulation of binding | positive regulation of cell differentiation | histone serine kinase activity | cell division | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | meiotic spindle organization | positive regulation of cell maturation | G2/M transition of mitotic cell cycle | phosphorylation | signal transduction involved in cell cycle checkpoint | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | mitotic centrosome separation | mitotic G1 DNA damage checkpoint | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | liver regeneration | regulation of cytokinesis | anterior/posterior axis specification | centrosome localization | regulation of protein metabolic process | cell cycle G2/M phase transition | histone phosphorylation | proteasome-mediated ubiquitin-dependent protein catabolic process | spindle assembly involved in meiosis | regulation of mitotic cell cycle | regulation of microtubule-based process | regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of cell cycle arrest | neuron differentiation | multicellular organism reproduction | protein metabolic process | regionalization | axis specification | gland development | G1 DNA damage checkpoint | centrosome cycle | histone kinase activity | spindle assembly involved in female meiosis I | response to wounding | regulation of intracellular signal transduction | cellular macromolecule catabolic process | anatomical structure development | developmental growth involved in morphogenesis | mitotic cell cycle | positive regulation of oocyte maturation | nuclear division | cell projection organization | metabolic process | positive regulation of cell development | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | microtubule organizing center localization | negative regulation of mitotic cell cycle | cellular protein localization | histone-serine phosphorylation | regulation of oocyte maturation | protein kinase activity | neuron projection development | organic substance metabolic process | animal organ development | signal transduction involved in mitotic cell cycle checkpoint | cytoskeleton organization | mitotic nuclear division | meiosis I | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | organonitrogen compound catabolic process | meiotic cell cycle | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | negative regulation of molecular function | signaling | covalent chromatin modification | regulation of protein binding | cell development | protein localization | cellular protein metabolic process | anatomical structure morphogenesis | cellular macromolecule localization | protein serine/threonine/tyrosine kinase activity | signal transduction involved in DNA damage checkpoint | regulation of developmental process | kinase activity | developmental process | organelle organization | positive regulation of cell cycle process | peptidyl-serine phosphorylation | cellular protein modification process | mitotic G1/S transition checkpoint | developmental cell growth | cell cycle phase transition | protein localization to cytoskeleton | signal transduction involved in mitotic G1 DNA damage checkpoint | positive regulation of metabolic process | chromosome organization | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | positive regulation of oocyte development | regulation of cell death | modification-dependent protein catabolic process | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | negative regulation of cell death | regulation of ubiquitin-dependent protein catabolic process | spindle organization | sexual reproduction | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization | positive regulation of mitotic nuclear division | signal transduction | regulation of signaling | female meiotic nuclear division | animal organ regeneration | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
condensed nuclear chromosome | supramolecular fiber | female germ cell nucleus | chromosome | centriole | intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | microtubule associated complex | microtubule organizing center | chromosome, centromeric region | condensed chromosome, centromeric region | cell body | cell | nuclear lumen | neuronal cell body | spindle pole centrosome | microtubule | cytoplasm | chromosome passenger complex | spindle | intracellular organelle | meiotic spindle | germ cell nucleus | germinal vesicle | centrosome | protein-containing complex | cell projection | pronucleus | nucleoplasm | midbody | axon hillock | condensed nuclear chromosome, centromeric region | cilium | nuclear chromosome | perinuclear region of cytoplasm | microtubule cytoskeleton | spindle pole | spindle microtubule | spindle midzone | membrane-bounded organelle | nucleus | organelle | axon | membrane-enclosed lumen | cytosol | cytoskeleton | mitotic spindle pole | intracellular | mitotic spindle | supramolecular complex | condensed chromosome
