QuickView for AURKB;jsessionid=5DEFB28AA6506D852E208E7810A68700 (gene)
- Gene Symbol:
- AURKB
Homo sapiens - Full name:
- aurora kinase B
- Synonyms:
- AIK2, AIM-1, AIM1, ARK-2, ARK2, AurB, IPL1, PPP1R48, STK-1, STK12, STK5, aurkb-sv1, aurkb-sv2, aurora kinase B, aurora kinase B-Sv1, aurora kinase B-Sv2, aurora- and Ipl1-like midbody-associated protein 1, aurora-1, aurora-B, aurora-related kinase 2, aurora/IPL1-related kinase 2, protein phosphatase 1, regulatory subunit 48, serine/threonine kinase 12, serine/threonine-protein kinase 12, serine/threonine-protein kinase 5, serine/threonine-protein kinase aurora-B
- Genomic Location:
- Chr 17: 8048774-8054608
- Description:
-
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
17p13.1
GO Molecular Function
kinase binding | cation binding | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | histone serine kinase activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | histone kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | protein serine/threonine/tyrosine kinase activity | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
regulation of telomere maintenance via telomerase | response to radiation | regulation of cell cycle process | abscission | positive regulation of macromolecule biosynthetic process | negative regulation of cell division | microtubule cytoskeleton organization involved in mitosis | positive regulation of cellular component organization | proteolysis | positive regulation of telomere capping | regulation of programmed cell death | peptidyl-amino acid modification | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | microtubule cytoskeleton organization | regulation of organelle organization | membrane organization | microtubule-based process | regulation of chromosome segregation | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | localization | proteolysis involved in cellular protein catabolic process | chromatin organization | cytokinetic process | protein localization to kinetochore | cytoskeleton-dependent cytokinesis | positive regulation of telomerase activity | negative regulation of nucleic acid-templated transcription | macromolecule localization | negative regulation of apoptotic process | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | spindle midzone assembly | spindle assembly | negative regulation of cellular metabolic process | regulation of binding | positive regulation of cytokinesis | regulation of lymphocyte apoptotic process | spindle checkpoint | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | regulation of G2/M transition of mitotic cell cycle | cellular component organization | negative regulation of cytokinesis | regulation of cell division | response to UV | regulation of telomere capping | response to stimulus | regulation of mitotic cell cycle phase transition | chromosome segregation | mitotic spindle organization | cellular response to light stimulus | negative regulation of G2/M transition of mitotic cell cycle | anaphase-promoting complex-dependent catabolic process | regulation of cell cycle phase transition | protein serine/threonine kinase activity | cellular protein catabolic process | cellular localization | proteasomal protein catabolic process | negative regulation of metabolic process | cellular component assembly | protein modification process | macromolecule modification | positive regulation of telomere maintenance via telomere lengthening | regulation of nucleic acid-templated transcription | organelle assembly | regulation of cell cycle G2/M phase transition | response to light stimulus | cleavage furrow formation | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | multicellular organism development | negative regulation of cell cycle G2/M phase transition | sister chromatid segregation | phosphorus metabolic process | regulation of telomere maintenance | regulation of catalytic activity | positive regulation of chromosome organization | positive regulation of cell cycle | regulation of gene expression | cell cycle | protein catabolic process | regulation of signal transduction by p53 class mediator | positive regulation of cellular metabolic process | regulation of telomerase activity | cellular response to radiation | mitotic cytokinesis checkpoint | negative regulation of lymphocyte apoptotic process | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | protein localization to organelle | negative regulation of binding | histone serine kinase activity | cell proliferation | cell division | negative regulation of B cell apoptotic process | cytokinesis | phosphorylation | positive regulation of telomere maintenance via telomerase | protein phosphorylation | phosphate-containing compound metabolic process | cellular response to UV | regulation of B cell apoptotic process | nuclear chromosome segregation | regulation of telomere maintenance via telomere lengthening | negative regulation of protein binding | regulation of cellular metabolic process | regulation of cytokinesis | positive regulation of DNA biosynthetic process | regulation of RNA metabolic process | histone phosphorylation | proteasome-mediated ubiquitin-dependent protein catabolic process | regulation of mitotic cell cycle | positive regulation of molecular function | protein metabolic process | histone kinase activity | protein localization to chromosome, centromeric region | regulation of intracellular signal transduction | cellular macromolecule catabolic process | anatomical structure development | mitotic cell cycle | nuclear division | metabolic process | histone H3-S28 phosphorylation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | cellular protein localization | histone-serine phosphorylation | membrane invagination | protein kinase activity | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | cytoskeleton organization | regulation of chromosome organization | mitotic nuclear division | attachment of spindle microtubules to kinetochore | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | organonitrogen compound catabolic process | regulation of cell communication | spindle elongation | negative regulation of molecular function | covalent chromatin modification | regulation of transcription, DNA-templated | regulation of protein binding | protein localization | negative regulation of leukocyte apoptotic process | cellular protein metabolic process | cellular macromolecule localization | protein serine/threonine/tyrosine kinase activity | positive regulation of telomere maintenance | positive regulation of DNA metabolic process | kinase activity | developmental process | organelle organization | regulation of DNA biosynthetic process | positive regulation of cell cycle process | peptidyl-serine phosphorylation | cellular protein modification process | negative regulation of transcription by RNA polymerase II | mitotic spindle assembly | positive regulation of metabolic process | chromosome organization | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | regulation of cell death | modification-dependent protein catabolic process | cell cycle checkpoint | negative regulation of cell death | aging | spindle organization | mitotic spindle midzone assembly | mitotic sister chromatid segregation | regulation of cellular component organization | mitotic spindle elongation | protein localization to chromosome | regulation of signaling | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
condensed nuclear chromosome | mitotic spindle midzone | supramolecular fiber | chromosome | intracellular membrane-bounded organelle | microtubule associated complex | microtubule organizing center | chromosome, centromeric region | condensed chromosome, centromeric region | cell | nuclear lumen | kinetochore | spindle pole centrosome | microtubule | cytoplasm | chromosome passenger complex | spindle | intracellular organelle | centrosome | chromocenter | protein-containing complex | nucleoplasm | midbody | condensed nuclear chromosome, centromeric region | nuclear chromosome | microtubule cytoskeleton | spindle pole | spindle microtubule | spindle midzone | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular | mitotic spindle | supramolecular complex | condensed chromosome
