QuickView for AXIN1 (gene)
- Gene Symbol:
- AXIN1
Homo sapiens - Full name:
- axin 1
- Synonyms:
- AXIN, PPP1R49, axin-1, axis inhibition protein 1, axis inhibitor 1, fused, mouse, homolog of, protein phosphatase 1, regulatory subunit 49
- Genomic Location:
- Chr 16: 277441-342465
- Description:
-
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingl...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
16p13.3
GO Molecular Function
structural molecule activity | beta-catenin binding | kinase binding | receptor signaling complex scaffold activity | protein kinase binding | enzyme binding | signaling adaptor activity | protein domain specific binding | ubiquitin-like protein ligase binding | armadillo repeat domain binding | identical protein binding | molecular adaptor activity | I-SMAD binding | protein binding | protein homodimerization activity | ubiquitin protein ligase binding | protein dimerization activity | protein-containing complex scaffold activity | SMAD binding
GO Biological Process
positive regulation of macromolecule biosynthetic process | positive regulation of peptidyl-threonine phosphorylation | negative regulation of cellular process | positive regulation of protein catabolic process | positive regulation of phosphate metabolic process | positive regulation of GTPase activity | positive regulation of cellular biosynthetic process | cellular process | regulation of ubiquitin-protein transferase activity | negative regulation of signaling | positive regulation of peptidyl-serine phosphorylation | canonical Wnt signaling pathway | beta-catenin destruction complex disassembly | positive regulation of protein kinase activity | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of canonical Wnt signaling pathway | beta-catenin destruction complex assembly | regulation of cellular process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | positive regulation of cellular protein metabolic process | cellular component organization | positive regulation of cellular protein catabolic process | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | regulation of intracellular steroid hormone receptor signaling pathway | regulation of protein ubiquitination | programmed cell death | positive regulation of proteolysis involved in cellular protein catabolic process | positive regulation of proteolysis | positive regulation of RNA biosynthetic process | cellular component assembly | cell-cell signaling | activation of protein kinase activity | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | apoptotic process | signaling adaptor activity | regulation of signal transduction | Wnt signaling pathway | regulation of MAPK cascade | regulation of catalytic activity | regulation of intracellular estrogen receptor signaling pathway | regulation of phosphorylation | regulation of gene expression | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | positive regulation of JNK cascade | positive regulation of intracellular signal transduction | positive regulation of hydrolase activity | regulation of cellular protein metabolic process | cellular protein-containing complex assembly | regulation of GTPase activity | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of molecular function | protein-containing complex assembly | positive regulation of protein modification process | regulation of kinase activity | regulation of intracellular signal transduction | cell surface receptor signaling pathway | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | cell death | positive regulation of kinase activity | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | regulation of JNK cascade | positive regulation of MAPK cascade | positive regulation of canonical Wnt signaling pathway | regulation of peptidyl-serine phosphorylation | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | protein-containing complex disassembly | positive regulation of phosphorylation | negative regulation of canonical Wnt signaling pathway | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of ubiquitin-protein transferase activity | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | positive regulation of Wnt signaling pathway | regulation of ubiquitin-dependent protein catabolic process | positive regulation of protein ubiquitination | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | protein-containing complex | plasma membrane | vesicle | perinuclear region of cytoplasm | beta-catenin destruction complex | membrane-bounded organelle | nucleus | organelle | cell periphery | cytosol | intracellular vesicle | intracellular | lateral plasma membrane | membrane
