QuickView for AXL (gene)

Gene Symbol:

AXL Homo sapiens

Full name:

AXL receptor tyrosine kinase

Synonyms:

ARK, JTK11, Tyro7, UFO, tyrosine-protein kinase receptor UFO, AXL oncogene, AXL transforming sequence/gene

Genomic Location:

Chr 19: 46416948-46459511

Description:

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm b...

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The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  TFIIA_Q6 ,  HP1SITEFACTOR_Q6 ,  CAGGTG_E12_Q6 ,  ACCAAAG_MIR9 ,  GGGCGGR_SP1_Q6 ,  CCCNNGGGAR_OLF1_01 ,  CTTTAAR_UNKNOWN ,  FREAC2_01 ,  MYOGENIN_Q6 ,  ARGGGTTAA_UNKNOWN ,  AACTTT_UNKNOWN ,  GGGTGGRR_PAX4_03 ,  TCCAGAG_MIR518C ,  CCTNTMAGA_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-9

miRNA binding sites
(Source: miRecords):

hsa-miR-1 Targeted Genes

Cytogenetic Map:

19q13.2

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