QuickView for ActB (gene)

Gene Symbol:

ACTB Homo sapiens

Full name:

actin beta

Synonyms:

BRWS1, PS1TP5BP1, actin, cytoplasmic 1, PS1TP5-binding protein 1, beta cytoskeletal actin

Genomic Location:

Chr 7: 5533312-5536747

Description:

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this...

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This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  GABP_B ,  RYTTCCTG_ETS2_B ,  SRF_Q6 ,  GCANCTGNY_MYOD_Q6 ,  AAANWWTGC_UNKNOWN ,  AACTGGA_MIR145 ,  HEB_Q6 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  GGGYGTGNY_UNKNOWN ,  TATA_C ,  SRF_Q4 ,  NFY_01 ,  MGGAAGTG_GABP_B ,  RAAGNYNNCTTY_UNKNOWN ,  AP2_Q6 ,  AP4_Q6_01 ,  SCGGAAGY_ELK1_02 ,  IK2_01 ,  SRF_Q5_01 ,  CTTTGT_LEF1_Q2 ,  RCGCANGCGY_NRF1_Q6 ,  CAGCTG_AP4_Q5 ,  GCTNWTTGK_UNKNOWN ,  AACTTT_UNKNOWN ,  ATGAAGG_MIR205 ,  CCAWWNAAGG_SRF_Q4 ,  HNF4_01_B ,  SRF_C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-486 ,  Predicted Gene Targets for miR-544

Cytogenetic Map:

7p22.1

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