Name: | Adenosine |
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PubChem Compound ID: | 10492175 |
Description: | A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. |
Molecular formula: | C10H13N5O4 |
Molecular weight: | 269.228 g/mol |
Name: | Adenosine |
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Name (isomeric): | DB00640 |
Drug Type: | small molecule |
Description: | A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. |
Synonyms: |
MEDR-640; Adenine Deoxy Nucleoside; Desoxyadenosine; Adenine Riboside; Adenyldeoxyriboside; Adenine Deoxyribonucleoside; Adenine Deoxyribose; Deoxyadenosine; USAF CB-10; 2'-Deoxyadenosine.
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Brand: | Nucleocardyl, Pallacor, Myocol, Adenocard, Adenosin, Boniton, Adenocor, Adensoine, Adenoscan, Sandesin |
Category: | Vasodilator Agents, Cardiac drugs, Antiarrhythmic Agents, Anti-Arrhythmia Agents, Analgesics |
CAS number: | 58-61-7 |
Indication: | Used as an initial treatment for the termination of paroxysmal supraventricular tachycardia (PVST), including that associated with accessory bypass tracts, and is a drug of choice for terminating stable, narrow-complex supraventricular tachycardias (SVT). Also used as an adjunct to thallous chloride TI 201 myocardial perfusion scintigraphy (thallium stress test) in patients who are unable to exercise adequately, as well as an adjunct to vagal maneuvers and clinical assessment to establish a specific diagnosis of undefined, stable, narrow-complex SVT. |
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Pharmacology: |
Adenosine is an endogenous nucleoside occurring in all cells of the body and is not chemically related to other antiarrhythmic drugs. Adenosine may exert its pharmacologic effects by activation of purine (cell surface A1 and A2 adenosine) receptors, as well as relax vascular smooth muscles through the reduction in calcium upta...
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Mechanism of Action: |
Adenosine slows conduction time through the AV node and can interrupt the reentry pathways through the AV node, resulting in the restoration of normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT), including PSVT associated with Wolff-Parkinson-White Syndrome. This effect may be mediated through the drug's activation ...
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Biotransformation: | Intracellular adenosine is rapidly metabolized either via phosphorylation to adenosine monophosphate by adenosine kinase, or via deamination to inosine by adenosine deaminase in the cytosol. |
Half Life: | Less than 10 secs |
Affected organisms: | Humans and other mammals |
Food interaction: |
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