QuickView for Aiolos (gene)
- Gene Symbol:
- IKZF3
Homo sapiens - Full name:
- IKAROS family zinc finger 3
- Synonyms:
- AIO, AIOLOS, ZNFN1A3, zinc finger protein Aiolos, zinc finger DNA binding protein Aiolos, zinc finger protein, subfamily 1A, 3 (Aiolos)
- Genomic Location:
- Chr 17: 35174724-35273967
- Description:
-
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
17q12-q21.1
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | nucleic acid binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | identical protein binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | positive regulation of macromolecule biosynthetic process | regulation of B cell activation | regulation of programmed cell death | regulation of immune system process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of cellular biosynthetic process | cellular process | mesoderm development | positive regulation of nitrogen compound metabolic process | tissue development | regulation of cell differentiation | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | regulation of lymphocyte differentiation | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of gene expression | positive regulation of cellular metabolic process | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | B cell activation | biosynthetic process | aromatic compound biosynthetic process | regulation of cellular metabolic process | regulation of RNA metabolic process | lymphocyte activation | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regulation of hemopoiesis | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of B cell differentiation | gene expression | regulation of cell activation | transcription, DNA-templated | cell activation | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | regulation of developmental process | developmental process | positive regulation of transcription, DNA-templated | regulation of B cell proliferation | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | immune system process | cellular metabolic process | regulation of cell death | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | plasma membrane | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytosol | intracellular | membrane
