QuickView for Akt2 (gene)
- Gene Symbol:
- AKT2
Homo sapiens - Full name:
- AKT serine/threonine kinase 2
- Synonyms:
- HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, RAC-beta serine/threonine-protein kinase, PKB beta, RAC-PK-beta, murine thymoma viral (v-akt) homolog-2, protein kinase Akt-2, protein kinase B beta, putative v-akt murine thymoma viral oncoprotein 2, rac protein kinase beta, v-akt murine thymoma viral oncogene homolog 2
- Genomic Location:
- Chr 19: 45428064-45483105
- Description:
-
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Danio rerio , Canis lupus familiaris , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
FOXO1_02 , RTAAACA_FREAC2_01 , GATA1_01 , VDR_Q3 , YATGNWAAT_OCT_C , AREB6_04 , STAT6_01 , CTTTGA_LEF1_Q2 , OSF2_Q6 , HNF4_01
- Cytogenetic Map:
-
19q13.2
GO Molecular Function
cation binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of glycogen biosynthetic process | response to radiation | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | activation of GTPase activity | regulation of intracellular protein transport | positive regulation of cellular component organization | protein localization to cell periphery | regulation of cellular localization | intracellular signal transduction | regulation of localization | regulation of carbohydrate metabolic process | regulation of programmed cell death | positive regulation of lipid catabolic process | peptidyl-amino acid modification | Schwann cell differentiation | establishment of localization | response to hormone | neuron death | negative regulation of cellular process | positive regulation of fatty acid oxidation | glucose metabolic process | regulation of protein localization to membrane | cell differentiation | nervous system development | generation of precursor metabolites and energy | neurogenesis | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of cellular component movement | membrane organization | intracellular transport | regulation of lipid transport | positive regulation of GTPase activity | positive regulation of cellular biosynthetic process | cellular process | peripheral nervous system development | regulation of glucose import | regulation of cell motility | localization | axon ensheathment | protein transport | regulation of mitochondrial membrane potential | positive regulation of membrane potential | macromolecule localization | negative regulation of apoptotic process | endomembrane system organization | regulation of cell cycle | positive regulation of catalytic activity | glycogen biosynthetic process | positive regulation of nitrogen compound metabolic process | myelin maintenance | establishment of localization in cell | response to peptide hormone | tissue development | cellular polysaccharide biosynthetic process | regulation of cellular process | regulation of apoptotic process | positive regulation of vesicle fusion | regulation of metabolic process | gliogenesis | positive regulation of cellular protein metabolic process | epithelium development | cellular response to organonitrogen compound | cellular component organization | response to stimulus | regulation of cellular protein localization | positive regulation of protein metabolic process | cellular response to light stimulus | response to light intensity | intracellular protein transport | cellular polysaccharide metabolic process | positive regulation of cellular protein localization | posttranscriptional regulation of gene expression | regulation of cell proliferation | peripheral nervous system myelin maintenance | polysaccharide metabolic process | response to peptide | positive regulation of glucose import | ensheathment of neurons | protein serine/threonine kinase activity | programmed cell death | cellular localization | negative regulation of transport | regulation of protein transport | protein modification process | regulation of peptide transport | cellular biosynthetic process | macromolecule modification | negative regulation of transmembrane transport | regulation of intracellular transport | retinal cell apoptotic process | regulation of membrane potential | response to nitrogen compound | apoptotic process | protein kinase B signaling | cellular response to hormone stimulus | response to light stimulus | system development | glycogen metabolic process | nitrogen compound metabolic process | positive regulation of organelle organization | regulation of fatty acid beta-oxidation | myelination | multicellular organism development | cellular response to peptide hormone stimulus | phosphorus metabolic process | mammary gland development | cellular response to insulin stimulus | regulation of catalytic activity | regulation of phosphorylation | polysaccharide biosynthetic process | plasma membrane organization | positive regulation of glucose import in response to insulin stimulus | protein localization to plasma membrane | regulation of gene expression | protein localization to membrane | organic substance transport | cellular response to peptide | positive regulation of intracellular protein transport | regulation of glucose import in response to insulin stimulus | insulin receptor signaling pathway | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular response to radiation | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | monosaccharide metabolic process | neuron apoptotic process | small molecule metabolic process | cellular carbohydrate metabolic process | peptide transport | regulation of cellular component movement | fat cell differentiation | positive regulation of hydrolase activity | regulation of fatty acid metabolic process | positive regulation of cell migration | negative regulation of ion transmembrane transport | carbohydrate biosynthetic process | positive regulation of glucose transmembrane transport | biosynthetic process | regulation of cellular protein metabolic process | glial cell differentiation | phosphorylation | negative regulation of ion transport | carbohydrate metabolic process | regulation of GTPase activity | protein phosphorylation | cellular response to high light intensity | phosphate-containing compound metabolic process | positive regulation of cellular response to insulin stimulus | cell communication | regulation of cellular metabolic process | positive regulation of protein localization to membrane | regulation of lipid catabolic process | regulation of protein metabolic process | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | positive regulation of transport | regulation of vesicle fusion | carbohydrate transport | positive regulation of molecular function | negative regulation of lipid transport | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | gland development | positive regulation of fatty acid beta-oxidation | positive regulation of fatty acid metabolic process | response to insulin | anatomical structure development | Schwann cell development | cell surface receptor signaling pathway | regulation of glucose metabolic process | metabolic process | negative regulation of fatty acid transport | positive regulation of glucose metabolic process | regulation of protein targeting | hexose metabolic process | oxidation-reduction process | negative regulation of programmed cell death | cellular protein localization | amide transport | regulation of vesicle-mediated transport | glucan biosynthetic process | protein kinase activity | organic substance metabolic process | cell death | regulation of glucose transmembrane transport | animal organ development | regulation of fatty acid oxidation | regulation of cellular response to insulin stimulus | regulation of phosphate metabolic process | mammary gland epithelium development | regulation of ion transmembrane transport | establishment of protein localization | positive regulation of intracellular transport | positive regulation of protein transport | positive regulation of carbohydrate metabolic process | transmembrane transport | signaling | glial cell development | cellular response to light intensity | intracellular protein transmembrane transport | response to high light intensity | cell development | energy reserve metabolic process | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | negative regulation of plasma membrane long-chain fatty acid transport | cellular macromolecule localization | cellular macromolecule biosynthetic process | regulation of cellular ketone metabolic process | regulation of ion transport | energy derivation by oxidation of organic compounds | kinase activity | developmental process | cellular glucan metabolic process | peptidyl-serine phosphorylation | cellular protein modification process | positive regulation of protein targeting to membrane | regulation of transport | regulation of fatty acid transport | response to organonitrogen compound | regulation of glycogen biosynthetic process | epithelial cell differentiation | regulation of anion transport | mammary gland epithelial cell differentiation | protein transmembrane transport | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of generation of precursor metabolites and energy | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell motility | regulation of translation | negative regulation of cell death | positive regulation of mitochondrial membrane potential | regulation of cellular component organization | myelination in peripheral nervous system | signal transduction | regulation of glycogen metabolic process | retinal rod cell apoptotic process | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | ruffle | cell projection membrane | cytoplasmic vesicle | cell | nuclear lumen | ruffle membrane | cytoplasm | intracellular organelle | leading edge membrane | protein-containing complex | cell projection | endomembrane system | nucleoplasm | plasma membrane | cell leading edge | vesicle | cytoplasmic region | endosome | cell cortex | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | early endosome | cytosol | intracellular vesicle | intracellular | membrane
