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QuickView for Aldh1a2 (gene)


Gene Symbol:
ALDH1A2 Homo sapiens Homo sapiens
Full name:
aldehyde dehydrogenase 1 family member A2
Synonyms:
RALDH(II), RALDH2, RALDH2-T, retinal dehydrogenase 2, RALDH 2, retinaldehyde-specific dehydrogenase type 2
Genomic Location:
Chr 15: 56032919-56145198
Description:
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mou...
Orthologs:
Mus musculus Rattus norvegicus Saccharomyces cerevisiae Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 15
15q21.3





GO Molecular Function

isoprenoid binding | retinoid binding | lipid binding | vitamin binding | catalytic activity | retinal dehydrogenase activity | aldehyde dehydrogenase (NAD) activity | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | oxidoreductase activity | 3-chloroallyl aldehyde dehydrogenase activity | small molecule binding | retinal binding

GO Biological Process

response to extracellular stimulus | brain development | limb development | response to nutrient levels | response to cytokine | muscle tissue development | positive regulation of apoptotic process | morphogenesis of an epithelium | isoprenoid biosynthetic process | regulation of programmed cell death | eye development | response to hormone | negative regulation of cellular process | embryonic appendage morphogenesis | cell differentiation | respiratory tube development | nervous system development | neurogenesis | generation of neurons | mesenchyme development | retinoic acid receptor signaling pathway | pattern specification process | cellular process | vitamin A metabolic process | limb morphogenesis | heart morphogenesis | response to estradiol | terpenoid biosynthetic process | diencephalon development | tissue development | cellular response to retinoic acid | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | pituitary gland development | retinoic acid biosynthetic process | hepaticobiliary system development | epithelium development | cellular lipid metabolic process | urogenital system development | head development | response to stimulus | vasculature development | mesenchymal cell development | monocarboxylic acid metabolic process | embryonic limb morphogenesis | midgut development | respiratory system development | alcohol metabolic process | regulation of cell proliferation | cardiac muscle tissue development | cardiovascular system development | retinoic acid receptor signaling pathway involved in somitogenesis | retinol metabolic process | cellular biosynthetic process | kidney development | embryo development | blood vessel development | anterior/posterior pattern specification | organic hydroxy compound metabolic process | retinoid metabolic process | system development | multicellular organism development | lipid metabolic process | regulation of hormone levels | embryonic digestive tract development | determination of bilateral symmetry | regulation of gene expression | forelimb morphogenesis | pancreas development | response to lipid | 9-cis-retinoic acid biosynthetic process | animal organ morphogenesis | liver development | embryonic forelimb morphogenesis | small molecule metabolic process | response to nutrient | stem cell differentiation | embryonic camera-type eye development | biosynthetic process | neural tube development | ureter maturation | hindbrain development | digestive tract development | response to vitamin A | lipid biosynthetic process | endocrine system development | sensory organ development | proximal/distal pattern formation | chordate embryonic development | striated muscle tissue development | cell communication | retinoic acid metabolic process | heart development | positive regulation of cell proliferation | embryo development ending in birth or egg hatching | renal system development | response to retinoic acid | retinal metabolic process | embryonic morphogenesis | drug metabolic process | carboxylic acid metabolic process | cellular aldehyde metabolic process | neuron differentiation | regionalization | response to organic substance | gland development | tissue morphogenesis | digestive system development | vitamin metabolic process | retinal dehydrogenase activity | aldehyde dehydrogenase (NAD) activity | anatomical structure development | metabolic process | mesenchymal cell differentiation | developmental maturation | oxidation-reduction process | embryonic organ development | 9-cis-retinoic acid metabolic process | positive regulation of cell death | morphogenesis of embryonic epithelium | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | organic substance metabolic process | response to vitamin | animal organ development | regulation of endothelial cell proliferation | forebrain development | positive regulation of programmed cell death | diterpenoid metabolic process | lung development | intracellular receptor signaling pathway | stem cell development | camera-type eye development | anatomical structure formation involved in morphogenesis | signaling | somite development | response to organic cyclic compound | cell development | regulation of epithelial cell proliferation | organic acid metabolic process | hormone metabolic process | anatomical structure morphogenesis | isoprenoid metabolic process | segmentation | developmental process | ureter development | tube development | negative regulation of cell proliferation | neural crest cell differentiation | somitogenesis | central nervous system development | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | regulation of cell death | oxidoreductase activity | circulatory system development | neural crest cell development | 3-chloroallyl aldehyde dehydrogenase activity | signal transduction | positive regulation of gene expression | multicellular organismal process | face development

GO Cellular Component

cell | cytoplasm | perinuclear region of cytoplasm | cytosol | intracellular