Name: | alitretinoin |
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PubChem Compound ID: | 449171 |
Molecular formula: | C20H28O2 |
Molecular weight: | 300.435 g/mol |
Synonyms: |
AIDS-060996; AGN-192013; ALRT-1057; LS-1328; Alitretinoin; 9-cis-RA; NSC-659772; 9-Cis-Retinoic Acid; LG-100057; C15493.
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Name: | alitretinoin |
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Name (isomeric): | DB00523 |
Drug Type: | small molecule |
Synonyms: |
ALRT-1057; Retinoic Acid; BAL4079; 9-cis-Retinoic acid
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Brand: | Panrexin, Panretin Gel, Panretin, Vesanoid, Renova, Panretyn, Retin-A Micro, Retin-A |
Category: | Keratolytic Agents, Antineoplastic Agents |
CAS number: | 5300-03-8 |
Indication: | For topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma. |
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Pharmacology: | Alitretinoin (9-cis-retinoic acid) is a naturally-occurring endogenous retinoid indicated for topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma. Alitretinoin inhibits the growth of Kaposi's sarcoma (KS) cells in vitro. |
Mechanism of Action: | Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells. |
Affected organisms: | Humans and other mammals |