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QuickView for Alitretinoin (compound)


PubChem
Name: alitretinoin
PubChem Compound ID: 449171
Molecular formula: C20H28O2
Molecular weight: 300.435 g/mol
Synonyms:
AIDS-060996; AGN-192013; ALRT-1057; LS-1328; Alitretinoin; 9-cis-RA; NSC-659772; 9-Cis-Retinoic Acid; LG-100057; C15493.
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DrugBank
Identification
Name: alitretinoin
Name (isomeric): DB00523
Drug Type: small molecule
Synonyms:
ALRT-1057; Retinoic Acid; BAL4079; 9-cis-Retinoic acid
Brand: Panrexin, Panretin Gel, Panretin, Vesanoid, Renova, Panretyn, Retin-A Micro, Retin-A
Category: Keratolytic Agents, Antineoplastic Agents
CAS number: 5300-03-8
Pharmacology
Indication: For topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma.
Pharmacology: Alitretinoin (9-cis-retinoic acid) is a naturally-occurring endogenous retinoid indicated for topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma. Alitretinoin inhibits the growth of Kaposi's sarcoma (KS) cells in vitro.
Mechanism of Action: Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells.
Affected organisms: Humans and other mammals

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