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QuickView for Alseroxylon (compound)

Name: Alseroxylon
Name (isomeric): DB00386
Drug Type: small molecule
Description: An alkaloidal extract from RAUWOLFIA.
Brand: Rautensin, Rauwiloid
Category: Adrenergic Uptake Inhibitors
CAS number: 8001-95-4
Indication: For the treatment of hypertension and as an adjunct in the management of angina pectoris.
Alseroxylon is a purified extract of Rauwolfia serpentina, containing reserpine and other amorphous alkaloids. Alseroxylon is an indole alkaloid antipsychotic and antihypertensive drug known to irreversibly bind to storage vesicles of neurotransmitters such as dopamine, norepinephrine, and serotonin. This leads to depletion of the neurotrans...
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Mechanism of Action:
The antihypertensive actions of alseroxylon are a result of its ability to deplete catecholamines from peripheral sympathetic nerve endings. Alseroxylon almost irreversibly blocks the accumulation of noradrenaline and dopamine into synaptic vesicles by inhibiting the Vesicular Monoamine Transporters (VMAT). This depletion ultimately affects the car...
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Affected organisms: Humans and other mammals
Drug interaction:
PseudoephedrineIncreased arterial pressure
PhenylpropanolamineIncreased arterial pressure
TerbutalineIncreased arterial pressure
FenoterolIncreased arterial pressure
OrciprenalineIncreased arterial pressure
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