Bookmark
Forward
QuickView for Aminophylline (compound)
PubChem
| Name: | Aminophylline |
|---|---|
| PubChem Compound ID: | 3048502 |
| Description: | A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications. |
| Molecular formula: | C21H28N8O5 |
| Molecular weight: | 472.498 g/mol |
| Synonyms: |
63907-40-4; Novophyllin
|
DrugBank
Identification
| Name: | Aminophylline |
|---|---|
| Name (isomeric): | DB01223 |
| Drug Type: | small molecule |
| Description: | A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications. |
| Synonyms: |
Aminophylline Anhydrous; Aminophylline Dye Free; Aminophyllin; Aminophylline Dihydrate
|
| Brand: | Cardophylin, Metaphylline, Vasofilina, Etilen-Xantisan Tabl., Dura-Tab S.M. Aminophylline, Inophylline, Diophllin, Thephyldine, Lasodex, Carena, Rectalad-Aminophylline, Grifomin, Ethophylline, Diaphylline, Stenovasan, Syntophyllin, Variaphylline, Theophyllin Aethylendiamin, Theophyldine, Theolone, Norofilina, Miofilin, Eurphyllin, Rectalad Aminophylline, Cardiofilina, Theophylline Ethylenediamine, Genophyllin, Phyllindon, Phyllocontin-350, Cardophyllin, Metaphyllin, Theophyllaminum, Theodrox, Lixaminol, Ammophyllin, Phylcardin, Somophyllin-O, Euufillin, Theolamine, Diuxanthine, Minaphil, Dobo, Cardiomin, Theophyllamine, Linampheta, Aminodur, Methophylline, Neophyiline, Theophyllin Ethylenediamine, Somophyllin O, Truphylline, Theophyline Ethylenediamine, Phyllocontin, Somophyllin, Peterphyllin, Aminocardol, Cariomin |
| Brand name mixture: | Quiex Liq(Aminophylline + Guaifenesin), Ami-Nesine Liq(Aminophylline + Guaifenesin), Quiex-Pred Sus(Aminophylline + Guaifenesin + Prednisolone), Quiex - Forte Syr(Aminophylline + Guaifenesin), Quiex-K1 Syr(Aminophylline + Guaifenesin + Potassium Iodide) |
| Category: | Respiratory Smooth Muscle Relaxants, Phosphodiesterase Inhibitors, Cardiotonic Agents, Bronchodilator Agents |
| CAS number: | 317-34-0 |
Pharmacology
| Indication: | For the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis. |
|---|---|
| Pharmacology: | Aminophylline is the ethylenediamine salt of theophylline. Theophylline stimulates the CNS, skeletal muscles, and cardiac muscle. It relaxes certain smooth muscles in the bronchi through PDE3 inhibition, produces diuresis, and causes an increase in gastric secretion. |
| Mechanism of Action: | Theophylline is structurally related to theobromine and caffeine. The precise mechanism of action of theophylline is not known, however, it is thought to be a phosphodiesterase inhibitor which may give a bronchodilatory effect. It also binds adenosine receptors. |
| Protein binding: | 60% |
| Half Life: | 7-9 hours |
| Clearance: | 0.29 mL/kg/min [postnatal age 3-15 days] 0.64 mL/kg/min [postnatal age 25-57 days] 1.7 mL/kg/min [ 1-4 years] 1.6 mL/kg/min [4-12 years] 0.9 mL/kg/min [13-15 years] 1.4 mL/kg/min [16-17 years] 0.65 mL/kg/min [Adults (16-60 years), non-smoking asthmatics] 0.41 mL/kg/min [Elderly (>60 years). liver, and renal function] 0.33 mL/kg/min [Acute pulmonary edema] 0.54 mL/kg/min [COPD->60 years, stable non-smoker >1 year] 0.48 mL/kg/min [COPD with cor pulmonale] 1.25 mL/kg/min [Cystic fibrosis (14-28 years)] 0.31 mL/kg/min [Liver disease -cholestasis] 0.35 mL/kg/min [cirrhosis] 0.65 mL/kg/min [acute hepatitis] 0.47 mL/kg/min [Sepsis with multi-organ failure] 0.38 mL/kg/min [hypothyroid] 0.8 mL/kg/min [hyperthyroid] |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
| ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug interaction: |
|
Targets
Enzymes
