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QuickView for Anisotropine Methylbromide (compound)
PubChem Substance
| Name: | octotropine methylbromide |
|---|---|
| PubChem Substance ID: | 9048 |
| Synonyms: |
Anisotropine Methylbromide; Endovalpin; Octatropine; Lytispasm; Methyloctatropine bromide; Valpin 50; Anisotropine methobromide
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DrugBank
Identification
| Name: | octotropine methylbromide |
|---|---|
| Name (isomeric): | DB00517 |
| Drug Type: | small molecule |
| Brand: | Anisotropine methobromide, Octatropine, Endovalpin, Methyloctatropine bromide, Lytispasm, Valpin 50 |
| Category: | Parasympatholytics, Anticholinergics |
| CAS number: | 80-50-2 |
Pharmacology
| Indication: | For use in conjunction with antacids or histamine H<sub>2</sub>-receptor antagonists in the treatment of peptic ulcer, to reduce further gastric acid secretion and delay gastric emptying. |
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| Pharmacology: |
Anisotropine methylbromide is a quaternary ammonium compound. Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents. Depending on the dose, anisotropine methylbromide may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have...
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| Mechanism of Action: |
Quaternary ammonium compounds such as anisotropine methylbromide inhibit the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of...
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| Absorption: | Gastrointestinal absorption is poor and irregular. Total absorption after an oral dose is about 10 to 25%. |
| Protein binding: | Not Known |
| Biotransformation: | Hepatic, by enzymatic hydrolysis. |
| Half Life: | Not Known |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
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Targets
