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QuickView for Apramycin (compound)


PubChem
Name: apramycin
PubChem Compound ID: 10098771
Molecular formula: C21H41N5O11
Molecular weight: 539.577 g/mol
DrugBank
Identification
Name: apramycin
Name (isomeric): DB04626
Drug Type: small molecule
Synonyms:
Nebramycin II
Category: Antibacterial Agents
CAS number: 37321-09-8
Pharmacology
Indication: For the treatment of bacterial infections in animals.
Mechanism of Action:
Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked h...
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Affected organisms: Enteric bacteria and other eubacteria
Interactions
Drug interaction:
TacrolimusAdditive renal impairment may occur during concomitant therapy with aminoglycosides such as Apramycin. Use caution during concomitant therapy.

Targets