Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward

QuickView for Aripiprazole (compound)

Name: aripiprazole
PubChem Compound ID: 11576259
Molecular formula: C23H27Cl2N3O2
Molecular weight: 462.333 g/mol
Name: aripiprazole
Name (isomeric): DB01238
Drug Type: small molecule
OPC-14597; OPC 31
Brand: Abilify, Abilitat
Category: Antipsychotic Agents, Antipsychotics
CAS number: 129722-12-9
Indication: For the treatment of schizophrenia and related psychotic disorders.
Aripiprazole is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Aripiprazole is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), dopamine Type 2 (D2), 1 and 2 adrenergic, and H1 histaminergic receptors. Aripiprazole acts as...
show more »
Mechanism of Action: Aripiprazole's antipsychotic activity is likely due to a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal cortex. Antagonism at D2 receptors relieves positive symptoms while antagonism at 5HT2A receptors relieves negative symptoms of schizophrenia.
Protein binding: >99%
Biotransformation: Hepatic.
Route of elimination: Less than 1% of unchanged aripiprazole was excreted in the urine and approximately 18% of the oral dose was recovered unchanged in the feces.
Half Life: 75-146 hours
Affected organisms: Humans and other mammals
Food interaction:
Avoid alcohol (possible additive effect to CNS).
Food has no significant effect on absorption.
Take without regard to meals.
Drug interaction:
CarbamazepineCarbamazepine, a strong CYP3A4 inducer, may decrease the serum concentration of aripiprazole by increasing its metabolism.
KetoconazoleKetoconazole may increase the effect of aripiprazole.
ItraconazoleItraconazole may increase the effect of aripiprazole.
TriprolidineThe CNS depressants, Triprolidine and Aripiprazole, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
TetrabenazineMay cause dopamine deficiency. Monitor for Tetrabenazine adverse effects.
show more »