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QuickView for Aripiprazole (compound)
PubChem
| Name: | aripiprazole |
|---|---|
| PubChem Compound ID: | 11576259 |
| Molecular formula: | C23H27Cl2N3O2 |
| Molecular weight: | 462.333 g/mol |
DrugBank
Identification
| Name: | aripiprazole |
|---|---|
| Name (isomeric): | DB01238 |
| Drug Type: | small molecule |
| Synonyms: |
OPC-14597; OPC 31
|
| Brand: | Abilify, Abilitat |
| Category: | Antipsychotic Agents, Antipsychotics |
| CAS number: | 129722-12-9 |
Pharmacology
| Indication: | For the treatment of schizophrenia and related psychotic disorders. |
|---|---|
| Pharmacology: |
Aripiprazole is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Aripiprazole is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), dopamine Type 2 (D2), 1 and 2 adrenergic, and H1 histaminergic receptors. Aripiprazole acts as...
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| Mechanism of Action: | Aripiprazole's antipsychotic activity is likely due to a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal cortex. Antagonism at D2 receptors relieves positive symptoms while antagonism at 5HT2A receptors relieves negative symptoms of schizophrenia. |
| Protein binding: | >99% |
| Biotransformation: | Hepatic. |
| Route of elimination: | Less than 1% of unchanged aripiprazole was excreted in the urine and approximately 18% of the oral dose was recovered unchanged in the feces. |
| Half Life: | 75-146 hours |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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Targets
Enzymes
