QuickView for Arnt (gene)

Gene Symbol:

ARNT Homo sapiens

Full name:

aryl hydrocarbon receptor nuclear translocator

Synonyms:

HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2, aryl hydrocarbon receptor nuclear translocator, class E basic helix-loop-helix protein 2, dioxin receptor, nuclear translocator, hypoxia-inducible factor 1, beta subunit

Genomic Location:

Chr 1: 149048810-149115810

Description:

This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is a...

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This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFMUE1_Q6 ,  CEBPA_01 ,  E4BP4_01 ,  CTTTGA_LEF1_Q2 ,  TTAYRTAA_E4BP4_01 ,  AML1_01 ,  GGGAGGRR_MAZ_Q6 ,  CEBP_Q2 ,  LEF1_Q2 ,  ATGCTGG_MIR338 ,  YY1_Q6 ,  GGATTA_PITX2_Q2 ,  AP4_Q6 ,  CAGGGTC_MIR504 ,  GCAAAAA_MIR129 ,  CEBPB_02 ,  ATGTTTC_MIR494 ,  AML1_Q6 ,  CEBP_Q3 ,  TEF_Q6 ,  CAGCTG_AP4_Q5 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  ACAGGGT_MIR10A_MIR10B ,  ATGTAGC_MIR221_MIR222

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-504

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Cytogenetic Map:

1q21.3

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