QuickView for Atp1a1 (gene)

Gene Symbol:

ATP1A1 Homo sapiens

Full name:

ATPase Na+/K+ transporting subunit alpha 1

Synonyms:

sodium/potassium-transporting ATPase subunit alpha-1, ATPase, Na+/K+ transporting, alpha 1 polypeptide, Na(+)/K(+) ATPase alpha-1 subunit, Na+/K+ ATPase 1, Na, K-ATPase, alpha-A catalytic polypeptide, Na,K-ATPase alpha-1 subunit, Na,K-ATPase catalytic subunit alpha-A protein, sodium pump subunit alpha-1, sodium-potassium ATPase catalytic subunit alpha-1, sodium-potassium-ATPase, alpha 1 polypeptide

Genomic Location:

Chr 1: 116717359-116748919

Description:

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, f...

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The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MAZ_Q6 ,  GGGAGGRR_MAZ_Q6 ,  TATCTGG_MIR488 ,  GGGYGTGNY_UNKNOWN ,  CCCNNGGGAR_OLF1_01 ,  NERF_Q2 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  CTTTAAR_UNKNOWN ,  GTGCCTT_MIR506 ,  TATTATA_MIR374 ,  CCACACA_MIR147 ,  ATGTAGC_MIR221_MIR222

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-384 ,  Predicted Gene Targets for miR-488

Cytogenetic Map:

1p13.1

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