QuickView for Atp2a1 (gene)

Gene Symbol:

ATP2A1 Homo sapiens

Full name:

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

Synonyms:

ATP2A, SERCA1, sarcoplasmic/endoplasmic reticulum calcium ATPase 1, ATPase, Ca++ transporting, cardiac muscle, fast twitch 1, SR Ca(2+)-ATPase 1, calcium pump 1, calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform, endoplasmic reticulum class 1/2 Ca(2+) ATPase

Genomic Location:

Chr 16: 28797310-28823331

Description:

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Muta...

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This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TCCCCAC_MIR491

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-491

Cytogenetic Map:

16p11.2

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