QuickView for B1R (gene)

Gene Symbol:

BDKRB1 Homo sapiens

Full name:

bradykinin receptor B1

Synonyms:

B1BKR, B1R, BDKRB2, BKB1R, BKR1, BRADYB1, B1 bradykinin receptor, BK-1 receptor, bradykinin B1 receptor, bradykinin receptor 1, bradykinin receptor B2

Genomic Location:

Chr 14: 95792312-95800853

Description:

Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de n...

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Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  TTANTCA_UNKNOWN ,  BACH2_01 ,  CEBPB_02 ,  BACH1_01 ,  CRX_Q4

Cytogenetic Map:

14q32.2

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