QuickView for B2M (gene)

Gene Symbol:

B2M Homo sapiens

Full name:

beta-2-microglobulin

Synonyms:

IMD43, beta-2-microglobulin, beta chain of MHC class I molecules, beta-2-microglobin

Genomic Location:

Chr 15: 42790977-42797649

Description:

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial ...

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This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  IRF1_01 ,  CEBPA_01 ,  MYOGNF1_01 ,  PAX4_02 ,  NF1_Q6 ,  IRF_Q6 ,  NF1_Q6_01 ,  ICSBP_Q6 ,  CTTTGT_LEF1_Q2 ,  ISRE_01 ,  STTTCRNTTT_IRF_Q6 ,  IRF2_01

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Cytogenetic Map:

15q21.1

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