QuickView for BCL10 (gene)
- Gene Symbol:
- BCL10
Homo sapiens - Full name:
- B cell CLL/lymphoma 10
- Synonyms:
- CARMEN, CIPER, CLAP, IMD37, c-E10, mE10, B-cell lymphoma/leukemia 10, CARD containing molecule enhancing NF-kB, CARD-containing apoptotic signaling protein, CARD-containing molecule enhancing NF-kappa-B, CARD-containing proapoptotic protein, CED-3/ICH-1 prodomain homologous E10-like regulator, cCARMEN, caspase-recruiting domain-containing protein, cellular homolog of vCARMEN, cellular-E10, hCLAP, mammalian CARD-containing adapter molecule E10
- Genomic Location:
- Chr 1: 85504047-85516171
- Description:
-
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
1p22.3
GO Molecular Function
protein self-association | kinase binding | enzyme activator activity | NF-kappaB binding | kinase regulator activity | protein kinase binding | protein kinase B binding | enzyme binding | molecular function regulator | ubiquitin-like protein ligase binding | identical protein binding | transcription coactivator activity | protein binding | transcription factor binding | ubiquitin protein ligase binding | kinase activator activity | enzyme regulator activity | protease binding | transcription coregulator activity | protein C-terminus binding
GO Biological Process
positive regulation of immune response | response to extracellular stimulus | protein homooligomerization | adaptive immune response | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | response to nutrient levels | negative regulation of immune system process | immune response-regulating signaling pathway | intracellular signal transduction | enzyme activator activity | positive regulation of apoptotic process | morphogenesis of an epithelium | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | negative regulation of mature B cell apoptotic process | negative regulation of cellular process | positive regulation of lymphocyte activation | immune response-activating cell surface receptor signaling pathway | T cell receptor signaling pathway | defense response | nervous system development | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | innate immune response activating cell surface receptor signaling pathway | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | toll-like receptor signaling pathway | regulation of cytokine biosynthetic process | epithelial tube morphogenesis | positive regulation of immune effector process | kinase regulator activity | negative regulation of apoptotic process | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of T cell receptor signaling pathway | tissue development | regulation of lymphocyte apoptotic process | positive regulation of interleukin-8 production | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | epithelium development | cellular component organization | interleukin-6 biosynthetic process | response to stimulus | cellular response to mechanical stimulus | positive regulation of innate immune response | embryonic epithelial tube formation | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of peptidase activity | response to stress | regulation of protein ubiquitination | tube morphogenesis | positive regulation of cell-cell adhesion | positive regulation of cysteine-type endopeptidase activity | programmed cell death | positive regulation of cytokine biosynthetic process | positive regulation of cell activation | epithelial tube formation | activation of innate immune response | positive regulation of proteolysis | response to molecule of bacterial origin | positive regulation of T cell activation | immune response-activating signal transduction | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | regulation of cell adhesion | embryo development | macromolecule modification | molecular function regulator | regulation of nucleic acid-templated transcription | apoptotic process | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | pattern recognition receptor signaling pathway | regulation of interleukin-8 biosynthetic process | multicellular organism development | regulation of peptidase activity | protein complex oligomerization | leukocyte mediated immunity | B cell apoptotic process | regulation of catalytic activity | regulation of phosphorylation | regulation of T cell activation | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | neural tube closure | positive regulation of cellular metabolic process | regulation of lymphocyte activation | negative regulation of lymphocyte apoptotic process | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of intracellular signal transduction | neural tube formation | positive regulation of hydrolase activity | Fc-epsilon receptor signaling pathway | T cell apoptotic process | biosynthetic process | negative regulation of B cell apoptotic process | neural tube development | regulation of cellular protein metabolic process | positive regulation of endopeptidase activity | interleukin-6 production | regulation of apoptotic signaling pathway | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of B cell apoptotic process | response to bacterium | response to fungus | chordate embryonic development | positive regulation of extrinsic apoptotic signaling pathway | cell communication | regulation of cellular metabolic process | lymphotoxin A biosynthetic process | regulation of cytokine production involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | embryo development ending in birth or egg hatching | transcription coactivator activity | regulation of RNA metabolic process | embryonic morphogenesis | positive regulation of molecular function | cytokine production | positive regulation of myeloid leukocyte cytokine production involved in immune response | protein-containing complex assembly | activation of immune response | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | protein ubiquitination | tissue morphogenesis | response to mechanical stimulus | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | kinase activator activity | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of programmed cell death | positive regulation of cytokine production involved in immune response | positive regulation of cell death | morphogenesis of embryonic epithelium | immune response | organic substance metabolic process | cell death | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | positive regulation of programmed cell death | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | antigen receptor-mediated signaling pathway | positive regulation of cytokine production | anatomical structure formation involved in morphogenesis | regulation of cell communication | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | I-kappaB kinase/NF-kappaB signaling | negative regulation of leukocyte apoptotic process | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | regulation of cytokine production | protein heterooligomerization | anatomical structure morphogenesis | regulation of endopeptidase activity | response to biotic stimulus | B cell mediated immunity | cytokine biosynthetic process | developmental process | Fc receptor signaling pathway | cellular protein modification process | tube development | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | innate immune response | cellular defense response | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | tube closure | stimulatory C-type lectin receptor signaling pathway | cytokine metabolic process | tube formation | positive regulation of metabolic process | positive regulation of interleukin-8 biosynthetic process | immunoglobulin mediated immune response | immune system process | cellular metabolic process | regulation of cell death | response to food | negative regulation of cell death | positive regulation of leukocyte cell-cell adhesion | positive regulation of protein ubiquitination | regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of apoptotic signaling pathway | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of mast cell cytokine production | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | integral component of membrane | intracellular membrane-bounded organelle | immunological synapse | T cell receptor complex | cell | plasma membrane protein complex | intrinsic component of membrane | microtubule | cytoplasm | cytoplasmic microtubule | intracellular organelle | receptor complex | membrane microdomain | protein-containing complex | plasma membrane | membrane raft | vacuole | perinuclear region of cytoplasm | microtubule cytoskeleton | lytic vacuole | membrane-bounded organelle | nucleus | organelle | lysosome | cell periphery | cytosol | cytoskeleton | lipopolysaccharide receptor complex | intracellular | membrane | supramolecular complex | CBM complex
